How I treat immunoblastic lymphoma?
The current standard of treatment for immunoblastic lymphoma is combined-modality treatment in the limited stage and chemotherapy only in the advanced stage. CHOP+R regimen (cyclophosphamide, hydroxydaunomycin [doxorubicin], Oncovin [vincristine], prednisone, and rituximab) is the therapy of choice.
What is immunoblastic?
Immunoblasts are the most immature members of the protective cells involved in an immune response. Activated B cells may differentiate into memory cells or plasma cells, while activated T cells may differentiate into memory cells or effector cells that aid in the immune response.
What is histiocytic lymphoma?
A rare, very aggressive (fast-growing) type of non-Hodgkin lymphoma (cancer that begins in the cells of the immune system). It is marked by large abnormal lymphoid cells that do not look like T cells or B cells.
Is AITL curable?
In general, relapsed lymphoma remains potentially curable; however, required approaches are significantly more aggressive and therefore riskier than the initial treatment. AITL cure remains elusive in the majority of patients.
What causes AITL?
The exact, underlying cause of AITL is unknown. It is believed that a dysfunctional immune system response to an unknown antigen ultimately leads to the development of the disorder. An antigen is any substance that causes the immune system to produce antibodies.
What are plasmacytoid lymphocytes?
Plasmacytoid lymphocytes are medium-sized cells with irregular, densely clumped nuclear chromatin, absent to indis- tinct nucleoli, and moderately abundant basophilic cytoplasm, often with a paranuclear clear zone.
Is histiocytic sarcoma a lymphoma?
Histiocytic sarcoma is a rare histiocytic neoplasm that can arise as a result of transdifferentiation from a low-grade B-cell lymphoma like CLL/SLL, among other hematopoietic neoplasms.
Is histiocytic sarcoma curable?
Untreated, the clinical course of disseminated histiocytic sarcoma is rapid and fatal. Localized histiocytic sarcoma is sometimes more slowly progressive, but can be extremely painful and cause a poor quality of life. Overall, response rates to treatment are poor and survival times are short (3-4 months).