What is the function of zinc finger?
Zinc finger proteins are among the most abundant proteins in eukaryotic genomes. Their functions are extraordinarily diverse and include DNA recognition, RNA packaging, transcriptional activation, regulation of apoptosis, protein folding and assembly, and lipid binding.
How do zinc fingers recognize DNA?
The binding of zinc finger is found to be distinct from many other DNA-binding proteins that bind DNA through the 2-fold symmetry of the double helix, instead zinc fingers are linked linearly in tandem to bind nucleic acid sequences of varying lengths. Zinc fingers often bind to a sequence of DNA known as the GC box.
What is a C2H2 zinc finger?
C2H2 zinc fingers (Cys2-His2) represent one of the most common domains found in the TFs of higher eukaryotes. The zinc finger structure is stabilized by the coordination of a zinc atom with two conserved cysteine residues at one end of the β sheet and with two conserved histidine residues at the α-helix C-terminus.
What is CRISPR biology?
CRISPR (/ˈkrɪspər/) (an acronym for clustered regularly interspaced short palindromic repeats) is a family of DNA sequences found in the genomes of prokaryotic organisms such as bacteria and archaea. They are used to detect and destroy DNA from similar bacteriophages during subsequent infections.
What is zinc finger gene editing?
Zinc finger nucleases (ZFNs) are a class of engineered DNA-binding proteins that facilitate targeted editing of the genome by creating double-strand breaks in DNA at user-specified locations.
Which hormone receptor has zinc?
The highly conserved DNA-binding domain of the steroid hormone receptors contains two ‘zinc finger’-like sequence motifs.
What does Ben winger study?
Ben Winger studies speciation, biogeography, and movement ecology (migration and dispersal) in birds. Ben uses a variety of approaches and data types in his research, including population genetics, genomics, phylogenetics, museum collections, and fieldwork.
Can Ben teach a cryo-ET course?
Ben enjoyed virtually teaching a graduate course on cryo-ET at the Basel Biozentrum. [Nov 2020] Our collaboration with the Guichard / Hamel Lab exploring the evolutionary diversity of the centriole’s cartwheel and proximal triplet microtubules is on the journal cover!!
What did Ben Ben do for Washington University?
Ben gave a virtual seminar for Washington University in St. Luis. Thank you for hosting, James Fitzpatrick! [Dec 2020] Our collaboration with the Jonikas Lab revealing the the structural interactions between the carbon-fixing enzyme Rubisco and the multivalent linker EPYC1 that drive phase separation of the pyrenoid.