Who discovered fibrous dysplasia of bone?

Who discovered fibrous dysplasia of bone?

The disease, which was first reported by Von Recklinghausen in 1891,3,4 was later described by Lichtenstein in 19381,5 and subsequently in 1942 along with Jaffe. The lesions have been reported to account for 2.5% to 7.0% of all benign bone tumors, with an equal predilection for both sexes.

What are the signs and symptoms of fibrous dysplasia?

What are the symptoms of fibrous dysplasia?

• A waddling walk.
• Bone deformity.
• Bone fractures.
• Bone pain (which happens when the fibrous tissue expands in the bone)
• Scoliosis (a sideways curve of the spine)

What is McCune-Albright syndrome?

McCune-Albright syndrome is a disorder that affects the bones, skin, and several hormone-producing (endocrine) tissues. People with McCune-Albright syndrome develop areas of abnormal scar-like (fibrous) tissue in their bones, a condition called polyostotic fibrous dysplasia.

Is fibrous dysplasia a disability?

Fibrous dysplasia is a condition where primitive bone cells proliferate inside the bone, weakening its structure and causing pain and disability.

Does fibrous dysplasia stop growing?

Fibrous dysplasia is a chronic disorder and is often progressive. Although the lesions may stabilize and stop growing, they do not disappear. Individual lesions may progress more rapidly in the polyostotic form of the condition and in growing children.

What is Mazabraud syndrome?

Mazabraud’s syndrome is a rare benign disorder characterized by the association of single or multiple intramuscular myxomas with fibrous dysplasia, which can develop in a single bone (monostotic) or in multiple bones (polyostotic).

Is fibrous dysplasia inherited?

The gene mutation associated with fibrous dysplasia occurs after conception, in the early stages of fetal development. Therefore, the mutation isn’t inherited from your parents, and you can’t pass it on to your children.

How do you get rid of fibrous dysplasia?

Although fibrous dysplasia is a genetic disorder, it’s caused by a gene mutation that’s not passed from parent to child. There’s no cure for the disorder. Treatment, which may include surgery, focuses on relieving pain and repairing or stabilizing bones.

What is Jaffe-Lichtenstein syndrome?

The term Jaffe-Lichtenstein syndrome is sometimes used synonymously with monostotic FD or to denote cases of polyostotic FD with café au lait spots, but no endocrine dysfunction. These disorders most likely represent a spectrum of disease associated with activating mutations of the GNAS1 gene.

What is fibrous dysplasia and what causes it?

Fibrous dysplasia can occur as part of a larger disorder such as McCune-Albright syndrome (fibrous dysplasia-café au lait spots-endocrine dysfunction) or Mazabraud syndrome (fibrous dysplasia-myxomas).

Is fibrous dysplasia monostotic or polyostotic?

The monostotic form is more common than the polyostotic form; according to some reports by a ratio of 4:1. A diagnosis of fibrous dysplasia is based upon identification of characteristic symptoms, a detailed patient history, a thorough clinical evaluation and a variety of specialized tests.