What is C1 test for?

What is C1 test for?

Your doctor can order blood tests to check your complement protein levels. One of these tests is the C1 esterase inhibitor test or C1-INH test. The C1-INH test can help your doctor determine if you have enough C1-INH.

How is C1 esterase inhibitor deficiency diagnosed?

HAE is diagnosed by the finding of low C1 esterase inhibitor level or function….Present with:

1. Stridor or respiratory distress due to laryngeal oedema.
2. Other signs of potential airway compromise eg hoarse voice, persistent cough, dysphagia or tongue swelling.
3. Severe abdominal pain or vomiting.

What is C1-INH deficiency?

Acquired angioedema due to C1-inhibitor (C1-INH) deficiency (AAE-C1-INH) is a serious condition that may result in life-threatening asphyxiation due to laryngeal edema. It is associated with malignant B-cell lymphoma and other disorders.

What does C1-INH do?

C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. Its main function is the inhibition of the complement system to prevent spontaneous activation but also as the major regulator of the contact system.

What is INH test?

This test measures the level of C1 Esterase Inhibitor (C1-INH) in the blood. C1 is one of the 9 major proteins in the complement system which helps the body protect itself from infections. C1 esterase inhibitor helps control the function of C1.

How long does C1 test take?

The practical exam will be taken at the DVLA and will take 2 hours to complete.

What is serum C1?

Clinical Information C1 inhibitor (C1-INH) is a multispecific protease inhibitor that is present in normal human plasma and serum, and which regulates enzymes of the complement, coagulation, fibrinolytic, and kinin-forming systems.

Does C1 inhibitor break down bradykinin?

The C1 inhibitor (C1 INH) is not only the inhibitor of activated C1r and C1s, but it is the key control protein of the plasma bradykinin-forming cascade.

What is the substrate for C1 esterase?

Although its name suggests specificity for C1, C1-INH acts on a variety of substrates including the contact system proteases (factor XII, plasma kallikrein), an intrinsic coagulation protease (factor XI) and the fibrinolytic proteases (plasmin, tissue plasminogen activator).

What is C1 esterase inhibitor antigen?

Clinical Information C1 esterase inhibitor blocks the activation of C1 (first component of the complement cascade) to its active form. The deficiency of C1 esterase inhibitor results in the inappropriate activation of C1 and the subsequent release of an activation peptide from C2 with kinin-like activity.

Why would my doctor order A C1-INH test?

Your doctor may order a C1-INH test if you have unexplained inflammation or swelling, known as edema. Your doctor may also order a C1-INH test to assess you for hereditary angioedema (HAE). Symptoms of HAE are: swelling in feet, face, hands, airway, and gastrointestinal wall

What is a C1-INH test for lupus?

Your doctor can use a C1-INH test to learn how you’re responding to treatment for autoimmune diseases, such as systemic lupus erythematosus (SLE), as well. How is the test administered? You don’t need to take special steps to prepare for a C1-INH test.

What is the normal range of C1 inh?

Normal levels of C1-INH generally range from 16 to 33 milligrams per deciliter. If your C1-INH levels are lower or higher than normal, it may be a sign of: hereditary or acquired angioedema

Is C1-INH deficiency inherited?

C1-INH deficiency can be either acquired or hereditary. An initial C1-INH workup includes testing for C1-INH and complement 4 (C4) levels. Document Properties… An error occurred while loading the PDF.