How do you interpret a vancomycin trough?
Trough concentrations are recommended for therapeutic monitoring of vancomycin, preferably acquired at steady-state (just before fourth dose). To avoid development of resistance, vancomycin trough levels should remain above 10.0 mcg/mL. Complicated infections require higher target levels, typically 15.0 to 20.0 mcg/mL.
What if vancomycin trough is high?
If the dose is too high, excessive concentrations of vancomycin can result in serious side effects, including hearing loss (ototoxicity) and kidney damage (nephrotoxicity). The goal is to find a dose for vancomycin that is both safe and effective.
When should trough levels be drawn?
A trough level is drawn immediately before the next dose of the drug is administered. A peak level is drawn 1 to several hours after the drug is administered (depending on the drug).
How long is Vanco trough good for?
Stability Requirements
| Temperature | Period |
|---|---|
| Room temperature | 3 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
| Freeze/thaw cycles | Stable x3 |
What can affect vancomycin levels?
The vancomycin trough concentration varies significantly in intensive care unit (ICU) patients. Sex, age, and the estimated glomerular filtration rate are independent factors affecting the trough concentration. The fixed-dose regimen of 2 g/day may be inappropriate in ICU patients.
What are peaks and troughs?
Peaks and troughs are the highest and lowest concentrations of a medication in an individual’s body. They are used to determine dosing intervals, or how much time should pass between each new administration of the drug.
What is C trough?
In medicine and pharmacology, a trough level or trough concentration (Ctrough) is the concentration reached by a drug immediately before the next dose is administered, often used in therapeutic drug monitoring.
When should vancomycin levels be taken?
Specimens for vancomycin trough concentrations should be obtained just prior to (that is, 30 minutes before) the fourth dose (including the loading dose, if given) or at steady state. At five half-lives, about 97% of steady-state serum concentrations will be reached.
What does a low trough level mean?
Peak and trough levels indicate drug levels in an individual’s body. A peak is the highest level of a medication in the blood, while a trough level indicates the lowest concentration. Troughs of medication concentration occur after the drug has been broken down and metabolized by the body.