How does topiramate help lose weight?
Topamax weight loss Topamax causes weight loss because it affects the appetite. People who take it and have a reduced appetite may feel hungry less often and eat less because of this. Studies have shown that Topamax may also speed up metabolism, which means that the body burns calories more quickly.
How is topiramate metabolized?
Topiramate is quickly absorbed after oral use. It has a half life of 21 hours and a steady state of the drug is reached in 4 days in patients with normal renal function. Most of the drug (70%) is excreted in the urine unchanged. The remainder is extensively metabolized by hydroxylation, hydrolysis, and glucuronidation.
What does Topamax do to your metabolism?
Topiramate reduced food intake acutely and increased metabolic rate. There were also significant reductions in leptin, insulin, and corticosterone.
What is the average weight loss on Topamax?
All patients lost a substantial amount of weight on topiramate treatment. The average weight loss was 22 lb (10 kg; range, 8–56 lb [4–25 kg]).
Will 25 mg of Topamax cause weight loss?
Topamax for weight loss Topamax isn’t approved for weight loss. However, the drug may reduce your appetite, which may lead you to lose weight. In clinical studies, weight loss occurred in 6% to 17% of people who took Topamax.
Does 100mg Topamax cause weight loss?
Migraine prevention – In adults using doses of 50 mg/day for migraine prevention, 6% of patients experienced weight loss, while in the 100 mg/day group, 9% of patients reported weight loss.
Is Topamax metabolized by the liver?
This is generally associated with lower interpatient variability in elimination kinetics. Approximately 20% of orally administered TPM is metabolized in the liver and this fraction may increase up to 50% in the presence of enzyme-inducing drugs, such as phenytoin or carbamazepine.
Does Topamax cause liver damage?
(Review of results of clinical trials of topiramate; most common side effects were CNS symptoms such as dizziness and somnolence; “There have been no cases of severe liver dysfunction or damage from topiramate”).
Can you lose weight on 50 mg of Topamax?
In the patients taking the lower 50 mg/day dose of topiramate, weight loss occurred in 6% of patients, and in the higher 200 mg/day dose, weight loss was reported in 17% of patients. Anorexia (loss of appetite), which may lead to weight loss, was also seen in 4% and 14% of patients, respectively.
Is Topamax hard on the kidneys?
Topomax can cause damage to kidney tubules that result in a failure to eliminate acid from the body. This may lead to kidney stones and other forms of damage to the kidneys over time. Topomax also has side effects that may be associated with weight loss and suppression of appetite.
Can you lose weight with topiramate?
There is definitely proof that topiramate helps with weight loss, however be sure to check with your doctor before using. Topamax contains an anti-convulsant property that calms the abnormal excitable nerve cells in the brain. This in turn helps you to get relief from binge eating that further avoids weight gain.
What does topiramate do for weight loss?
Topiramate (or Topamax) is an anti-convulsant medicine. It helps to lose weight, as it supresses the appetite. You can take topamax either with or without food, both in tablet or capsule form, however it can have a bitter taste with it. Is one of the most effective home remedies that together, with diet and exercise, can be used for weight loss.
Does topiramate give you energy?
Energy increased is found among people who take Topamax, especially for people who are female, 40-49 old , have been taking the drug for 10+ years, also take medication Vimpat, and have Depression.
Why does Topamax making me lose weight?
According to the Topamax website, one side effect of the drug is changes in the sensation of taste due to a reduction of saliva. In some patients, this change in taste may be so severe that they lose the pleasure associated with food, which may lead to weight loss. The American Diabetes Association reports other theories as well.