What is the function of CD24?
CD24 is a highly glycosylated protein with a small protein core that is linked to the plasma membrane via a glycosyl-phosphatidylinositol anchor. CD24 is primarily expressed by immune cells but is often overexpressed in human tumors. In cancer, CD24 is a regulator of cell migration, invasion and proliferation.
What are CD24 cells?
CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface.
What is CD24 MADE OF?
CD24 is a small but extensively glycosylated protein linked to the cell surface by means of a glycosyl-phosphatidylinositol anchor. In this study we found that CD24 is present in membrane vesicles characterized as exosomes that were isolated from the urine of normal individuals.
Do neutrophils express CD24?
CD24 is highly expressed on neutrophils, but little is known about its modulation during infection and inflammation. Therefore, we evaluated the ability of LPS and a large number of cytokines to modulate the expression of this molecule.
Is CD24 a receptor?
The ability of CD24 to act as a membrane-organizing factor further supports a role for CD24 to regulate receptor oligomerization and localization. Thus, it is possible that CD24 can rapidly or contextually alter its associations, which may be another mechanism through which it exerts context-specific effects.
What is CD44 and CD24?
CD44, a hyaluronic acid receptor, is one of the most commonly studied surface markers, which is expressed by almost every tumour cell. CD24, a heat stable antigen, is another surface marker expressed in many tumour types.
What is CD44 +/ CD24?
CD44/CD24 and ALDH1 are widely used cancer stem cell (CSC) markers in breast cancer. However, their expression is not always consistent even in the same subtype of breast cancer. Systematic comparison of their functions is still lacking.
What does CD stand for in CD24?
General information on CD24 Recombinant Protein: The cluster of differentiation system (CD) is commonly used as a cell marker for immunophenotyping. Different types of cells in the immune system can be identified by surface CD molecules related to cellular immune function.
What does CD24 do in the immune system?
CD24 also mediates homeostatic proliferation in T cells ( Li et al., 2004 ), and can negatively regulate inflammation by inhibiting dendritic cell (DC) activation ( Chen et al., 2009 ). CD24 also acts outside the immune system.
How does CD24 modulate activation of a target cell?
Mechanistically, CD24 likely modulates activation of this partner through direct physical interaction mediated by its modifiable glycoslyations. The variable nature of CD24-mediated effects can thus be explained by its in cis association with unique, cell-type specific signaling partners (Figure 1A ).
What is heat-stable antigen (CD24)?
The heat-stable antigen (mouse CD24) was identified 30 years ago. 1 Since then, CD24 has been extensively used as a marker for the differentiation of hematopoietic and neuronal cells, in addition to tissue and tumor stem cells.
Is CD24 a rheostat?
CD24 as a Signaling Rheostat Our opinion is that CD24 functions as a rheostat to modulate responses transduced by partnered cell surface receptor (s), and that these partners define the biological outcomes observed.