What are the 5 classes of anti HIV drugs?
Classes of ARTs include the following:
- Nucleoside or nucleotide reverse transcriptase inhibitors (NRTIs)
- Nonnucleoside reverse transcriptase inhibitors (NNRTIs)
- Protease inhibitors (PIs)
- Integrase inhibitors (IIs)
- Fusion inhibitors (FIs)
- Chemokine receptor antagonists (CRAs)
Which of the medicine is used as anti HIV?
FDA-Approved HIV Medicines
| Drug Class | Generic Name (Other names and acronyms) |
|---|---|
| NRTIs block reverse transcriptase, an enzyme HIV needs to make copies of itself. | lamivudine (3TC) |
| tenofovir disoproxil fumarate (tenofovir DF, TDF) | |
| zidovudine (azidothymidine, AZT, ZDV) | |
| Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) |
How do nucleoside drugs work?
Nucleoside Reverse Transcriptase Inhibitors (nucleoside analogues, NRTIs or nukes) When the HIV virus enters a healthy cell, it attempts to make copies of itself. It does this by using an enzyme called reverse transcriptase. The NRTIs work because they block that enzyme.
How does nucleoside reverse transcriptase inhibitor work?
Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.
What is Acriptega?
Acriptega Tablet is a combination of antiretrovirals medicines. It is prescribed to treat HIV (human immunodeficiency virus) infection. It boosts up the immunity to fight against HIV to manage or treat AIDS (acquired immunodeficiency syndrome).
What is Acriptega used for?
It is indicated for the treatment of Human Immunodeficiency Virus (HIV) infected adults and adolescents above 12 years of age weighing at least 40 kg (see Precautions and Pharmacology: Pharmacodynamics under Actions).
How do RT inhibitors work?
What is the difference between NRTI and Nnrti?
So NRTIs are like another zip giving the zipper another track to follow. NNRTIs work by sitting in a binding site in the virus structure and this is a bit like having an object that blocks the teeth of the zipper, so the zipper cannot get past the block.
What do nucleoside analogs do?
The nucleoside analogues resemble naturally occurring nucleosides and act by causing termination of the nascent DNA chain. They are believed to inhibit viral replication by several mechanisms, either by competitive inhibition of the viral polymerase or by DNA chain termination.
What are the treatment options for HIV neuropathy?
Treatment of HIV neuropathies depends on the type. Typical HIV polyneuropathy requires good control of HIV infection. Antiretroviral toxic neuropathy may require the cessation of the offending drug.
How do integrase inhibitors for HIV work?
Integrase inhibitors work by blocking the incorporation of HIV’s DNA into the host cell’s DNA, a process known as integration. They do so by inhibiting a viral enzyme known as integrase.
How does HIV affect the nervous system?
HIV can affect peripheral sensory and motor nerves, thoracic nerves, cranial nerves or autonomic nerves. HIV neuropathy can manifest itself in multiple ways.
What are the symptoms of HIV mononeuropathy?
Often non-painful stimuli, such as touching, can elicit pain sensation. In addition, at later stages of the illness, there may be weakness of the muscles in the feet and hands. In HIV mononeuropathy, the symptoms depend on which nerve is affected.