What is pegylated liposomal doxorubicin?
Pegylated liposomal doxorubicin (Doxil, Caelyx) is a formulation of doxorubicin in poly(ethylene glycol)-coated (stealth) liposomes with a prolonged circulation time and unique toxicity profile. We review the preclinical and clinical pharmacology as well as recent clinical data obtained in specific cancer types.
Is Doxil pegylated?
When the disease recurs, the patient and physician are presented with a host of chemotherapy options. One drug that is increasingly being used is pegylated liposomal doxorubicin (DOXIL ® [US], Caelyx ® [outside US]; Tibotec Therapeutics, a division of Ortho Biotech Products, L.P., Bridgewater, NJ, USA.
What is non pegylated liposomal doxorubicin?
Non-pegylated liposomal doxorubicin (Myocet®) has been studied in clinical trials in the treatment of several types of solid tumor, including metastatic breast cancer (16).
What is an important feature of doxorubicin HCL liposomal?
Liposomal doxorubicin is an anthracycline-type chemotherapy drug that is used to treat certain types of cancer (e.g., ovarian cancer, AIDS-related Kaposi’s sarcoma, multiple myeloma). It works by slowing or stopping cancer cell growth.
What is a pegylated drug?
PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect.
What is the difference between Doxil and doxorubicin?
Doxil is the trade name for doxorubicin liposomal. In some cases, health care professionals may use the trade name doxil when referring to the generic drug name doxorubicin liposomal. Drug type: Doxorubicin (liposomal) is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug.
What are the side effects of doxorubicin?
Side Effects
- Cough or hoarseness accompanied by fever or chills.
- darkening or redness of the skin (if you recently had radiation treatment)
- fast or irregular heartbeat.
- fever or chills.
- joint pain.
- lower back or side pain accompanied by fever or chills.
- pain at the injection site.
What are PEGylated nanoparticles?
Coating the surface of nanoparticles with polyethylene glycol (PEG), or “PEGylation”, is a commonly used approach for improving the efficiency of drug and gene delivery to target cells and tissues.
Is caelyx the same as doxorubicin?
Liposomal doxorubicin is a chemotherapy drug that is also called by the brand names Caelyx or Myocet. It contains the chemotherapy drug doxorubicin (Adriamycin) wrapped up in a fatty covering called a liposome. It is a treatment for some types of cancer, including: breast cancer.