Is RORO 3 a P2X 3 antagonist?

Is RORO 3 a P2X 3 antagonist?

RO-3 is a selective homomeric P2X 3 and heteromeric P2X 2/3 receptor antagonist (pIC 50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X 1, P2X 2, P2X 4, P2X 5 and P2X 7 receptors (IC 50 > 10 μ M). Attenuates nociceptive sensitivity in animal models of pain.

What does R03 stand for?

The NIH has standardized the Small Grant (R03) application characteristics, requirements, preparation, and review procedures in order to accommodate investigator-initiated (unsolicited) applications.

What is the R03 grant mechanism?

The R03 grant mechanism will support small research projects that can be carried out in a short period of time with limited resources. The NIH has standardized the Small Grant (R03) application characteristics, requirements, preparation, and review procedures in order to accommodate investigator-initiated (unsolicited) applications.

How much does an investigator-initiated R03 project cost?

This website describes the use of the investigator-initiated R03. You may request a project period of up to two years and a budget for direct costs of up $50,000 per year. No preliminary data are required but may be included if available. The Research Strategy may not exceed 6 pages.