What is the most common primary immunodeficiency disease?

What is the most common primary immunodeficiency disease?

IgA deficiency is the most common PID, occurring in approximately 1 in 300 to 1 in 500 persons [4]. The clinical presentation of PIDs is highly variable; however, most disorders involve increased susceptibility to infection.

How common is SCID in India?

The incidence of SCID was previously reported at approximately 1 in 100,000 but the implementation of TREC assay for Newborn screening of SCID revealed the true incidence of SCID to be 1 in 58,000 live births (95% CI, 1 in 46,000–1 in 80,000) for typical SCID, leaky/atypical SCID, and Omenn syndrome (5).

What are primary immunodeficiency diseases?

Primary immune deficiency diseases (PIDDs) are rare, genetic disorders that impair the immune system. Without a functional immune response, people with PIDDs may be subject to chronic, debilitating infections, such as Epstein-Barr virus (EBV), which can increase the risk of developing cancer. Some PIDDs can be fatal.

Is IgA deficiency a primary immunodeficiency?

Immunoglobulin A (IgA) deficiency is a common primary immunodeficiency characterized by undetectable serum amounts of IgA and a concomitant lack of secretory IgA. Other immunoglobulin levels are normal.

How many types of primary immunodeficiency are there?

There are more than 200 different forms of primary immune deficiency diseases (PIDDs).

How many primary immunodeficiency are there?

There are more than 300 types of primary immunodeficiency disorders, and researchers continue to identify more.

What is a moderate primary immunodeficiency?

People with primary immunodeficiency (PI) have an immune system that does not work correctly. This means that people with PI are more likely to get and become severely ill from infections. There are more than 400 types of PI that vary in severity, which affects how early they are detected.

Which is better IgG or IgM?

While IgM antibodies are short-lived and may indicate that the virus is still present, IgG antibodies are more durable and could be the key to lasting immunity.

What is the Indian Society for primary immune deficiency?

The Indian Society for Primary Immune Deficiency (ISPID) was founded in 2011 in close liaison with the Foundation for Primary Immunodeficiency Diseases (FPID), USA. The Indian Council of Medical Research (ICMR) has also been at the forefront of activities related to PIDs in India.

What are primary immunodeficiency disorders (PIDs)?

Primary immunodeficiency disorders (PIDs) are a group of genetic defects characterized by abnormalities of one or more components of the immune system. While there have been several advances in diagnosis, management, and research in the field of PIDs, they continue to remain underdiagnosed, especially in the less affluent countries.

Is there progress in the field of PIDs in India?

In this review, we highlight the progress in the field of PIDs in India over the last 25 years, the difficulties faced by clinicians across the country, the current state of PIDs in India and the future prospects.