What is the purpose of aspirin synthesis experiment?
The purpose of this lab was to synthesize Aspirin and measure the synthesized Aspirin’s purity. By calculating the theoretical yield based on the original amount of Salicylic acid, one could determine the actual yield percentage of the reaction.
How aspirin is synthesized?
Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. It is odourless, colourless to white crystals or crystalline powder.
What is the purpose of sulfuric acid in aspirin synthesis?
Making aspirin In this case just a few drops of sulphuric acid added to the mixture means that there are some free positive hydrogen ions in the solution which can bind to the ethanoic anhydride. This makes it more active and speeds up the reaction. To ensure the reaction goes as quickly as possible we have to heat it.
Why is water added in aspirin synthesis?
The mixture is heated to form the acetylsalicylic acid (C9H8O4) and acetic acid (C2H4O2). After the reaction takes place, water is added to destroy the excess acetic anhydride and cause the product to crystallize. The aspirin is then collected, purified by recrystallization, and its melting temperature measured.
What is the balanced chemical equation for the synthesis of aspirin?
*The chemical equation corresponding to the synthesis reaction is: C7H6O3 + (CH3CO)2O → C9H804 + CH3COOH.
What is mechanism of action of aspirin?
Aspirin is non-selective and irreversibly inhibits both forms (but is weakly more selective for COX-1). It does so by acetylating the hydroxyl of a serine residue. Normally COX produces prostaglandins, most of which are pro-inflammatory, and thromboxanes, which promote clotting.
What is the limiting reagent in aspirin synthesis?
salicylic acid
The acetic acid which is water soluble, can be separated from the aspirin by filtration. The salicyclic acid will be the limiting reagent. As far as the calculation of the theoretical yield is concerned, we assume that every mole of salicylic acid will be converted to aspirin or acetylsalicylic acid.
What is the catalyst in the synthesis of aspirin?
phosphoric acid
To prepare aspirin, salicylic acid is reacted with an excess of acetic anhydride. A small amount of a strong acid is used as a catalyst which speeds up the reaction. In this experiment, phosphoric acid will be used as the catalyst. The excess acetic acid will be quenched with the addition of water.
What impurities can be present in synthesized aspirin?
The aspirin produced in this activity is not pure. It is often contaminated with salicylic acid, acetic acid, and/or sulfuric acid. Students should not taste their aspirin. Fill the 50-mL buret with acetic anhydride.
What is the theoretical yield of aspirin in your synthesis?
2.520 grams
Thus, the calculated value of crude synthesized aspirin was 3.029 grams. Following purification, the calculated mass of the final aspirin product was 2.169 grams. The calculated theoretical yield was 2.520 grams.
What is the balanced equation for the synthesis of aspirin?
The chemical equation for the synthesis of aspirin is C7H6O3 + C4H6O3 –> C9H8O4 +C2H4O2, which is a reaction of salicylic acid with acetic anhydride in the presence of phosphoric acid. The byproduct is acetic acid. Adding cold water stops the reaction, and the products are filtered, yielding aspirin.
Why is acetic anhydride used in aspirin synthesis?
Acetic anhydride is the preferred acid derivative to synthesize aspirin commercially because the acetic acid produced in this reaction can be used again, by converting it back into acetic anhydride . In a 125-mL erlenmeyer flask, add 2 g salicylic acid (put the flask on the balance, and zero it).
How to synthesize aspirin?
Aspirin is synthesized through the reaction of salicylic acid with acetyl anhydride which causes a chemical reaction that turns salicylic acid’s hydroxyl group into an acetyl group, (R—OH → R—OCOCH3). For the reaction to take place, an inorganic acid such as phosphoric acid is used as a catalyst.
Does aspirin inhibit protein synthesis?
Results showed that the placebo group had 75% higher protein synthesis at the skeletal muscle than the ibuprofen or acetaminophen group. These painkillers didn’t effect overall body breakdown, but did effect protein synthesis at the muscle. Aspirin also has a effect on decreasing protein synthesis.