What is the drug didanosine used for?
Didanosine is used in combination with other medicines for the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Didanosine will not cure or prevent HIV infection or AIDS.
How do you take didanosine?
Didanosine should be taken on an empty stomach since food may keep it from working properly. Didanosine oral liquid should be taken at least 30 minutes before or 2 hours after you eat. Swallow the delayed-release capsule whole. Do not break, crush, chew, or open it.
How does didanosine work as an antiviral agent?
Didanosine is used along with other medications to treat human immunodeficiency virus (HIV) infection. Didanosine is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood.
What are Zalcitabine used for?
Zalcitabine is used for: Treating HIV infection. It is used in combination with other medicines. Zalcitabine in a nucleoside reverse transcriptase inhibitor. It works by blocking the growth of HIV.
What are the side effect of didanosine?
Common side effects may include:
- nausea, vomiting, diarrhea, stomach pain;
- rash;
- headache; or.
- changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
Who manufactures didanosine?
Also at the end of that ten-year period, the NIH licensed didanosine to Barr Laboratories under a non-exclusive license, and didanosine became the first generic anti-HIV drug marketed in the United States.
What is the brand name for indinavir?
CRIXIVAN® (indinavir sulfate) is an inhibitor of the human immunodeficiency virus (HIV) protease.
What is chemical name of didanosine?
Didanosine (ddI, DDI), sold under the brand name Videx, is a medication used to treat HIV/AIDS. It is used in combination with other medications as part of highly active antiretroviral therapy (HAART)….Didanosine.
| Clinical data | |
|---|---|
| ECHA InfoCard | 100.129.182 |
| Chemical and physical data | |
| Formula | C10H12N4O3 |
| Molar mass | 236.231 g·mol−1 |
What is another name for stavudine?
Stavudine (d4T), sold under the brand name Zerit among others, is an antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use with other antiretrovirals.
Is Zalcitabine still used?
Zalcitabine appears less potent than some other nucleoside RTIs, has an inconvenient three-times daily frequency and is associated with serious adverse events. For these reasons it is now rarely used to treat human immunodeficiency virus (HIV), and it has even been removed from pharmacies entirely in some countries.
What is the mechanism of action of Zalcitabine?
Mechanism of Action: The triphosphate form of zalcitabine inhibits HIV reverse transcriptase by competing for incorporation into viral DNA as well as chain termination of the viral DNA due to the lack of a 3′-OH group.
What is didanosine used to treat?
Didanosine (ddI, DDI), marketed under the trade names Videx, is a medication used to treat HIV/AIDS. It is used in combination with other medications as part of highly active antiretroviral therapy (HAART). It is of the reverse-transcriptase inhibitor class.
What is the role of the kidneys in the treatment of didanosine?
An enteric-coated formulation is now marketed as well. Elimination is predominantly renal; the kidneys actively secrete didanosine, the amount being 20% of the oral dose.
What is the half life of didanosine?
Oral absorption of didanosine is fairly low (42%) but rapid. Food substantially reduces didanosine bioavailability, and the drug should be administered on an empty stomach. The half-life in plasma is only 1.5 hours, but in the intracellular environment more than 12 hours.
Who synthesized didanosine (DDA)?
The related pro-drug of didanosine, 2′,3′-dideoxyadenosine (ddA), was initially synthesized by Morris J. Robins (professor of Organic Chemistry at Brigham Young University) and R.K. Robins in 1964.