What is busulfan and fludarabine?
Abstract. Busulfan and cyclophosphamide (BuCy) are currently the most widely used myeloablative regimen to treat malignancies with allogeneic stem cell transplantation. Fludarabine has considerable efficacy in both immunosuppression and tumor cells killing with a minimal extramedullary toxicity.
What is busulfan and cyclophosphamide?
Busulfan and cyclophosphamide (BuCy) is a frequently used myeloablative conditioning regimen for allogeneic hematopoietic cell transplantation (allo-HCT). Theoretical considerations and pharmacological data indicate that application of busulfan prior to subsequent cyclophosphamide (BuCy) may trigger liver toxicity.
Is busulfan an immunosuppressant?
Busulfan is an alkylating agent used to treat chronic myelogenous leukemia. Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow.
What is busulfan used for?
Busulfan is used treat a certain type of chronic myelogenous leukemia (CML; a type of cancer of the white blood cells). Busulfan is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.
Is busulfan chemotherapy?
What is busulfan? Busulfan is a chemotherapy drug. You might have it as a treatment for: chronic myeloid leukaemia (CML)
What is the basic ring of busulfan?
Busulfan is an alkylsulfonate. It is an alkylating agent that forms DNA-DNA interstrand crosslinks between the DNA bases guanine and adenine and between guanine and guanine. This occurs through an SN2 reaction in which the relatively nucleophilic guanine N7 attacks the carbon adjacent to the mesylate leaving group.
Does fludarabine cause infertility?
Hemolytic anemia has rarely occurred in people receiving one or more cycles of fludarabine. Patients are monitored for this condition. Your fertility, meaning your ability to conceive or father a child, may be affected by fludarabine. Please discuss this issue with your health care provider.
What type of drug is busulfan?
Busulfan is a chemotherapy drug. It is a treatment for chronic myeloid leukaemia (CML) and some types of blood cancers called myelodysplastic syndromes (MDS). Or you might have it as a treatment before a stem cell or bone marrow transplant.
What is the mechanism of action of busulfan?
Busulfan is a bifunctional alkylating agent. 3-5 Following systemic absorption, carbonium ions are rapidly formed, resulting in alkylation of DNA. This leads to breaks in the DNA molecule as well as cross-linking of the twin strands, resulting in interference of DNA replication and transcription of RNA.