What type of receptor is HER2 and why is it important?
HER2 proteins are receptors on breast cells. Normally, HER2 receptors help control how a healthy breast cell grows, divides, and repairs itself. But in about 10% to 20% of breast cancers, the HER2 gene doesn’t work correctly and makes too many copies of itself (known as HER2 gene amplification).
What type of receptor is HER2?
HER2 belongs to the human epidermal growth factor receptor family, which includes EGFR (alias HER1), HER3, and HER4. HER2 works as an oncogene in several cancers including breast cancers, manifesting its effect of carcinogenesis mainly by overexpression or due to gene amplification.
Is HER2 an epidermal growth factor receptor?
Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth factor receptor family having tyrosine kinase activity.
What is metronomic capecitabine?
Metronomic chemotherapy involves continuous administration of cytostatic drugs at low doses without longer drugfree intervals. Capecitabine (Xeloda) is a prodrug, given in a tablet formulation, that is selectively converted to 5-Fluorouracil at the tumor sites.
What is HER2 EGFR?
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer.
What cancers can be HER2-positive?
Cancers that may be HER2 positive include breast, bladder, pancreatic, ovarian, and stomach cancers. Also called c-erbB-2 positive and human epidermal growth factor receptor 2 positive.
What does Erbb stand for?
ERBB
| Acronym | Definition |
|---|---|
| ERBB | Employee Retirement Benefits Board (Washington State Department of Retirement Systems) |
| ERBB | East River Blues Band |
Can DCIS be HER2-positive?
Background. Previous studies have reported up to 50% of ductal carcinoma in situ (DCIS), is HER2 positive, but the frequency of HER2-positive invasive breast cancer (IBC) is lower. The aim of this study is to characterise HER2 status in DCIS and assess its prognostic value.
Where is the HER2 receptor located?
The HER2 receptor is a 1255 amino acid, 185 kD transmembrane glycoprotein located at the long arm of human chromosome 17 (17q12) [6].
How good is capecitabine?
Capecitabine, an oral fluoropyrimidine, has been demonstrated to be at least as effective as bolus 5-fluorouracil/leucovorin in terms of time to disease progression, time to treatment failure, and overall survival, but achieves significantly higher response rates and has the advantage of oral administration.
Where is carcinoma found in the body?
Carcinoma is the most common type of cancer. It begins in the epithelial tissue of the skin, or in the tissue that lines internal organs, such as the liver or kidneys. Carcinomas may spread to other parts of the body, or be confined to the primary location.