When do you stop procainamide infusion?
Please note, the use of procainamide should be stopped if any of the following occurs, arrhythmia suppression, onset of hypotension, QRS complex widens by greater than 50% of the pretreatment width or the maximum dose of 17 mg per kg is reached.
How is procainamide toxicity treated?
In overdose, charcoal can be considered after securing the airway but the mainstay treatment for toxicity is treatment of underlying rhythms using sodium bicarbonate, magnesium, and overdrive pacing. In chronic toxicity, procainamide has been linked to a drug-induced systemic lupus erythematosus syndrome.
What is a contraindication of procainamide?
Procainamide is contraindicated in patients with second- or third-degree AV block, unless controlled by a pacemaker, due to the risk of additive cardiac depression. In general, use procainamide cautiously in patients with certain types of cardiac disease.
What is IV procainamide?
Descriptions. Procainamide injection is used to treat irregular heartbeats and to slow an overactive heart. When the heart has a normal heartbeat (rhythm), it will work more efficiently. Procainamide works by slowing the nerve impulses in the heart and reducing the sensitivity of heart tissues.
Why is procainamide used?
Procainamide is used to treat abnormal heart rhythms. It works by making your heart more resistant to abnormal activity.
How long does it take procainamide to work?
Procainamide is given IV or PO with the onset of action in 10 to 30 minutes.
What is the most common adverse effects of procainamide?
Common side effects of Pronestyl (procainamide hydrochloride) include nausea, vomiting, loss of appetite, diarrhea, bitter taste in the mouth, dizziness, tired feeling, flushing (warmth, redness, or tingly feeling), and itching or rash.
Can procainamide cause fever?
Your doctor will order certain lab tests to check your response to procainamide. If you experience any of the following symptoms, call your doctor immediately: fever, chills, sore throat, bruising, bleeding, muscle aches or weakness, stomach or chest pain, skin rash, or blisters on the cheek, tongue and lips.
What is the most common adverse effect of procainamide *?
How long does procainamide stay in your system?
Pharmacokinetics. Procainamide is rapidly eliminated (half-life, 3 to 4 hours) by hepatic metabolism and renal excretion of unchanged drug.
Can you use procainamide long term?
Introduction. Procainamide is an oral antiarrhythmic agent that has been in use for more than 60 years. Long term procainamide therapy is known to induce hypersensitivity reactions, autoantibody formation and a lupus-like syndrome but is a rare cause of clinically apparent acute liver injury.
What are the possible adverse effects of procainamide?
The adverse effects of procainamide include cardiac toxicity, bradycardia, hypotension, drug-induced lupus erythematosus-like syndrome, and blood dyscrasias. QRS, QTc, and PR prolongation are the most potentially harmful cardiac side effects of procainamide and may become worse when levels of procainamide rise.
How long does it take for procainamide to work?
Procainamide is given IV or PO with the onset of action in 10 to 30 minutes. The loading dose is of IV procainamide is 10 to 17 mg/kg and administered at a rate of 20 to 50 mg/min. Alternatively, this may be dosed at 100 mg every 5 minutes in adult patients.
What does pprocainamide mean?
Procainamide injection is used to treat irregular heartbeats and to slow an overactive heart. When the heart has a normal heartbeat (rhythm), it will work more efficiently. Procainamide works by slowing the nerve impulses in the heart and reducing the sensitivity of heart tissues.
How many milligrams of Procainamide can you give a person?
The loading dose is of IV procainamide is 10 to 17 mg/kg and administered at a rate of 20 to 50 mg/min. Alternatively, this may be dosed at 100 mg every 5 minutes in adult patients. The administration of this maintenance dose is from 1 to 4 mg/minute; however, the manufacturer labeling recommends 2 to 6 mg/minute.