What is translocation renal cell carcinoma?
Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. These translocations most commonly involve the TFE3 gene on locus Xp11. 2 and less commonly involve the TFEB gene on locus 6p21.
What is metastatic clear cell carcinoma?
Metastatic renal cell carcinoma is cancer in your kidneys that has spread to other parts of your body. It’s also called stage IV renal cell cancer. Cancer is harder to treat after it spreads, but it’s not impossible.
What is MiT family translocation?
The MiT family translocation renal cell carcinoma comprises Xp11 translocation renal cell carcinoma harboring TFE3 gene fusions and t(6;11) renal cell carcinoma harboring TFEB gene fusion.
What is SDH deficient renal cell carcinoma?
Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a rare RCC subtype that is caused by biallelic mutation of one of the four subunits of the SDH complex (SDHA, B, C, and D) and results in inactivation of the SDH enzyme.
What is collecting duct carcinoma?
Collecting duct carcinoma (CDC) is a rare and aggressive form of kidney cancer that begins in the collecting duct of the kidney. Many people with CDC have no signs or symptoms until the cancer is at an advanced stage. Symptoms may include flank pain, unexplained weight loss, or blood in the urine.
What is clear cell renal carcinoma?
Clear cell renal cell carcinoma, or ccRCC, is a type of kidney cancer. The kidneys are located on either side of the spine towards the lower back. The kidneys work by cleaning out waste products in the blood. Clear cell renal cell carcinoma is also called conventional renal cell carcinoma.
What is a Sdhb mutation?
An additional, somatic mutation that deletes the normal copy of the gene is needed to cause renal cell cancer and other tumor types. Mutations of the SDHB gene lead to a reduction in the amount of SDHB protein in the cell and loss of SDH enzyme activity.
What is Xp11 TFE3 renal carcinoma?
Xp11 / TFE3 Translocation Carcinoma of the Kidney. Definition. Renal carcinoma comprising a large fraction of renal carcinomas occurring in young patients and associated with translocations involving the TFE3 gene at chromosome Xp11.2.
How reliable is TFE3 immunohistochemistry in the diagnosis of melanocytosis?
TFE3 immunohistochemistry may be less reliable than reported in the literature with numerous false positives Rare melanocytic variants are HMB45, MelanA pos, MiTF and actin negative TFE3 immunohistochemistry may be less reliable than reported in the literature with numerous false positives
How is translocation renal cell carcinoma (TRCC) diagnosed?
In translocation renal cell carcinoma, a gene called TFE3 is broken apart and rearranged. Doctors will look for this change in chromosomes to confirm that your cancer is translocation renal cell carcinoma. What is the prognosis for someone with TRCC? The estimate of how a disease will affect you long-term is called prognosis.
What is Xp11 translocation renal cell carcinoma (RCC)?
Argani P, Hicks J, De Marzo AM, Albadine R, Illei PB, Ladanyi M, Reuter VE, Netto GJ. Xp11 translocation renal cell carcinoma (RCC): extended immunohistochemical profile emphasizing novel RCC markers.