What does cholesterol efflux mean?
Cholesterol efflux, a part of RCT, is a pathway transferring intracellular cholesterol from macrophages or other cells to extracellular acceptors such as apolipoprotein A-I (apoA-I) of high-density lipoprotein (HDL).
What is cholesterol efflux capacity?
A low plasma level of high-density lipoprotein (HDL) cholesterol (HDL-C) is associated with cardiovascular risk. A key cardioprotective property of HDL is cholesterol efflux capacity (CEC), the ability of HDL to accept cholesterol from macrophages.
What is HDL efflux?
Cholesterol efflux capacity (CEC) is an in-vitro assay that measures the ability of an individual’s HDL to promote cholesterol efflux from cholesterol donor cells such as macrophages. CEC of HDL is a predictor of cardiovascular risk independent of HDL-C levels.
How does efflux of cholesterol from the cells to HDL particles occur?
Net efflux of cholesterol mass from the cells involves passive diffusion of cholesterol molecules through the aqueous phase and down their concentration gradient between the membrane and HDL; the concentration gradient is maintained by LCAT-mediated esterification of cholesterol molecules in the HDL particles.
What do you mean by efflux?
Definition of efflux 1 : something given off in or as if in a stream. 2a : effluence sense 2. b : a passing away : expiration. Other Words from efflux Example Sentences Learn More About efflux.
How is cholesterol efflux measured?
For measuring specific cholesterol efflux, apoA-I is used to reflect ABCA1-dependent efflux whilst HDL or reconstituted HDL for ABCG1 and SR-B1-dependent pathways. Cyclodextrin is often used to assess non-specific efflux.
What is another name for ABCA1?
Function of ABCA1 Membrane Protein ABCA1, also known as cholesterol efflux regulatory protein (CERP), functions as a cholesterol membrane transporter involved in the regulation of cellular cholesterol and phospholipid homeostasis.
What does HDL do to cholesterol in the blood?
HDL (high-density lipoprotein), or “good” cholesterol, absorbs cholesterol and carries it back to the liver. The liver then flushes it from the body. High levels of HDL cholesterol can lower your risk for heart disease and stroke.
What is another word for efflux?
In this page you can discover 18 synonyms, antonyms, idiomatic expressions, and related words for efflux, like: emanation, effluence, discharge, outflow, outpour, gush, outpouring, spate, move, influx and inflow.
What is the meaning of efflux and influx?
Movement of ions into cells is called influx while movement of ions out of the cells is called efflux.
What is the role of ABCA1?
The ABCA1 gene belongs to a group of genes called the ATP-binding cassette family, which provides instructions for making proteins that transport molecules across cell membranes. The ABCA1 protein is produced in many tissues, with high amounts found in the liver and in immune system cells called macrophages.
What is the cellular function of ABCA1?
ABCA1 mediates the efflux of cholesterol and phospholipids to lipid-poor apolipoproteins (apoA1 and apoE) (reverse cholesterol transport), which then form nascent high-density lipoproteins (HDL). It also mediates the transport of lipids between Golgi and cell membrane.