What do you mean by steric hindrance?
Steric hindrance is the slowing of chemical reactions due to steric bulk. It is usually manifested in intermolecular reactions, whereas discussion of steric effects often focus on intramolecular interactions. Steric hindrance is often exploited to control selectivity, such as slowing unwanted side-reactions.
What is the synonym for hindrance?
barrier, deterrent, drawback, handicap, hitch, impediment, interference, interruption, obstacle, snag, stumbling block, albatross, baggage, bar, catch, check, clog, crimp, drag, encumbrance.
What does the word steric mean?
Definition of steric : relating to or involving the arrangement of atoms in space : spatial.
What does sterically mean in chemistry?
sterical. / (ˈstɛrɪk, ˈstɪər-) / adjective. chem of, concerned with, or caused by the spatial arrangement of atoms in a molecule.
Does steric hindrance increase stability?
Steric hindrance is known to affect the stability, reactivity, and radical trapping ability of stable nitroxide radicals.
Does steric hindrance increase reactivity?
The rate of reaction drastically increases. Just remember: the smaller the goalie, the greater will be the chances to score. *one way to rationalize the poor reactivity of nucleophiles in hydrogen-bonding (i.e. polar protic) solvents is that they make the nucleophile more sterically hindered.
What are examples of hindrances?
An example of a hindrance is a road block preventing you from getting where you need to go. Something which hinders: something that holds back or causes problems with something else. High-heeled shoes may be fashionable, but they can also be a hindrance to walking. The state or act of hindering something.
Is it hindrance or hindrance?
A hindrance is something in the way, an obstacle. Hindrance refers to the act of slowing things down, or the thing that’s causing the problem, like your “helpful” little sister. It’s the noun form of the verb hinder, which is “to get in the way.”
What is steric strain?
Steric strain The overall strain in a molecule due to the non-bonded interactions of atoms or groups of atoms that are in close proximity so that their electrons repel each other.
Is Sterical a word?
adj. Of or relating to the spatial arrangement of atoms in a molecule. [ster(eo)- + -ic.] ster′i·cal·ly adv.
Is steric hindrance a repulsion?
As the atoms near each other, their outer (valence) electrons interact to repel each other, and this repulsion energy increases very rapidly as the distance r decreases. This increase in energy as atoms are crowded together is called steric repulsion or steric hindrance.
What is meant by steric hindrance?
Steric Hindrance a lowering of the rate of a chemical reaction caused by the blocking of the reactive site of a molecule by adjacent atoms or groups of atoms. For example, the esterification of di-ortho-substituted benzoic acids (I,a) is quite difficult, as is the hydrolysis of their esters (I,b):
What is another word for hindrance?
other words for hindrance. MOST RELEVANT. barrier. deterrent. drawback. handicap. hitch. impediment. interference.
What is meant by stersteric interference?
ster·ic hin·drance. interference with or inhibition of a seemingly feasible reaction (usually synthetic) because the size of one or another reactant prevents approach to the required interatomic distance.
Does steric hindrance affect selectivity of Michael adducts?
Furthermore, the steric hindrance in the transition-state also affects the selectivities of Michael adducts. This movement could be due to less steric hindrance with Ala 44, Met 67, and Ala 74-75 and aiding the ligand to be in the hydrophobic pocket and the remaining part of the ligand to be in the polar region of the protein.