What is Hydroxymethylglutaryl?
Listen to pronunciation. (hy-DROK-see-MEH-thul-GLOO-tuh-ril-koh-EN-zime A ree-DUK-tays in-HIH-bih-ter) A substance that blocks an enzyme needed by the body to make cholesterol and lowers the amount of cholesterol in the blood.
Where does cholesterol synthesis occur?
Cholesterol synthesis takes place in the cytoplasm and in the endoplasmic reticulum (ER). The first step in the pathway catalyzed by 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase (HMGCS) occurs in the cytosol while the subsequent steps occur in the ER.
What does HMG CoA stand for?
β-Hydroxy β-methylglutaryl-CoA (HMG-CoA), also known as 3-hydroxy-3-methylglutaryl coenzyme A, is an intermediate in the mevalonate and ketogenesis pathways. HMG-CoA is a metabolic intermediate in the metabolism of the branched-chain amino acids, which include leucine, isoleucine, and valine.
How does Atorvastatin work in the body?
Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.
What do anti statins do?
Statins help lower low-density lipoprotein (LDL) cholesterol, also known as “bad” cholesterol, in the blood. They draw cholesterol out of plaque and stabilize plaque, Blaha says.
What is the importance of cholesterol synthesis?
Cholesterol is essential for making the cell membrane and cell structures and is vital for synthesis of hormones, vitamin D and other substances. Cell membrane synthesis – Cholesterol helps to regulate membrane fluidity over the range of physiological temperatures.
Why statins are given at bedtime?
They act by inhibiting the enzyme HMG CoA reductase, which controls synthesis of cholesterol in the liver. Most manufacturers of statins recommend that they are taken at night, on the basis of physiological studies which show that most cholesterol is synthesised when dietary intake is at its lowest.
Does HMG CoA reductase make cholesterol?
3-Hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase produces mevalonate, an important intermediate in the synthesis of cholesterol and essential nonsterol isoprenoids.
What can be synthesized from cholesterol?
Cholesterol also serves as a precursor for the biosynthesis of steroid hormones, bile acid and vitamin D. Cholesterol is the principal sterol synthesized by all animals. In vertebrates, hepatic cells typically produce the greatest amounts.
How is cholesterol synthesized in the liver?
LIVER CHOLESTEROL METABOLISM Cholesterol is both synthesized by cells and taken in with food intake. The liver is the principal site for cholesterol homeostasis maintenance carried out in many mechanisms, such as biosynthesis, via 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR, E.C. 1.1.
What is the normal range for cholestrol?
NOTE: All values are expressed in mg/dL and mmol/L for US and international measurements. TOTAL CHOLESTEROL LEVELS: Less than 200 mg/dL or 5.1 mmol/L – Optimal. 200 – 239 mg/dL or 5.1 – 6.1 mmol/L – Mildly High.
What are the different types of cholesterol numbers?
Cholesterol numbers are classified : 1. Normal cholesterol level :- under 5mmol/L ( under 200mg/dl) -under 4mmol/L for those with high risk. 2. Borderline cholesterol: levels between 5 -7.5mmol/L. 3.High cholesterol levels: above 7.5mmol/L. Your cholesterol number is classified as border- line, which means it is above the normal range,
What does it mean if my cholesterol number is border line?
Your cholesterol number is classified as border- line, which means it is above the normal range, but not quite in the high range yet. We recommend you make some lifestyle changes in order to lower your cholesterol down to the normal ranges. The lifestyle changes you need to make are as following: 1.
How big is a 5-760x U-joint?
Spicer 5-760X 1 pounds 3.7 x 3.6 x 1.4 inches USA 5-760X No 5-760X 5-760X Manufacturer’s warranty can be requested from customer service. Click here to make a request to customer service. Would you like to tell us about a lower price? Video Player is loading. This is a modal window. Spicer U-joint Kit, 1310-WJ Series.