Is emodin safe?
Conclusions. In summary, our studies establish that 1) emodin is safe for use in both male and female mice when given at 20, 40, and 80 mg/kg doses for 12 weeks and 2) sex differences should be considered when establishing dosing intervals for emodin treatment.
What is emodin good for?
Emodin has been widely used in the treatment of cancer, asthma, osteoarthritis, diabetes, atherosclerosis, AD and hepatic disease. Furthermore, many recent studies have shown that emodin in conjunction with various chemotherapeutic agents is effective in the elimination of tumour cell growth.
What is emodin found in?
Emodin (6-methyl-1,3,8-trihydroxyanthraquinone) is a naturally occurring anthraquinone derivative found in roots and leaves of various plants, fungi and lichens. For a long time it has been used in traditional Chinese medicine as an active ingredient in herbs.
What is the structure of emodin?
Emodin is a trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens.
Is anthraquinone toxic?
Anthraquinone is not toxic and therefore there would be no expected cumulative effects from common mechanisms of toxicity. The Agency has considered anthraquinone in light of the relevant safety factors in FQPA and FIFRA.
Is aloin an anthraquinone?
Aloin is an anthraquinone glycosyl, meaning that its anthraquinone skeleton has been modified by the addition of a sugar molecule. Anthraquinones are a common family of naturally occurring yellow, orange, and red pigments of which many have cathartic properties, attributes shared by aloin.
Is emodin a glycoside?
A new anthraquinone glycoside, emodin-8-O-sophoroside (a diglucoside), has been isolated in 0.0027% yield from dried Indian senna leaves (J. Although senna is not noted for its volatile components, Tutin in his 1913 publication had observed the ‘strongly aromatic dark-coloured essential oil’.
Can anthraquinones be absorbed through the skin?
* Anthraquinone can affect you when breathed in and may be absorbed through the skin.
What foods contain anthraquinone?
Introduction. Anthraquinones (AQs) are found in rhubarb root, Senna leaf and pod, Cascara, Buckhorn, and Aloe, and they are widely used in laxative preparations.
What are the medical uses of emodin?
Due to its laxative effect, emodin has been used in traditional Chinese medicine for obesity-related diseases.
Is Imodium ® A-D liquid safe for children?
Take comfort in knowing that IMODIUM ® A-D Liquid for use in children is the only over-the-counter brand anti-diarrheal that’s FDA-approved for children ages 6 and up. IMODIUM ® A-D for Children 6 and up How IMODIUM ® products work IMODIUM ® products contain Loperamide, which works with your body to help restore its natural rhythm.
Is emodin toxic to the human body?
Emodin has been shown to impair embryonic development in mouse blastocysts, and in vitro studies have demonstrated a dose-dependent inhibitory effect on sperm motility but not sperm viability. None well documented. Concentration- and time-dependent toxicity of emodin has been observed in liver and kidney cell lines.
Why choose Imodium ® A-D caplets & liquid?
It works faster than Loperamide alone. IMODIUM ® A-D Caplets & Liquid work fast so you can get back to doing the things you love. Take comfort in knowing that IMODIUM ® A-D Liquid for use in children is the only over-the-counter brand anti-diarrheal that’s FDA-approved for children ages 6 and up.