Why does thiazide diuretics cause hyperglycemia?
Hypokalemia has been associated with the development of hyperglycemia following the administration of thiazides, possibly through impairment of potassium-dependent insulin release in response to glucose load.
Do thiazides increase blood sugar?
These data suggest that thiazide-induced hypokalemia is associated with increased blood glucose. Treatment of thiazide-induced hypokalemia may reverse glucose intolerance and possibly prevent the future development of diabetes.
How does hydrochlorothiazide increase blood sugar?
It is possible that hydrochlorothiazide increases the production of glucose from the liver, and because beta-blockers limit the absorption of glucose into cells, the use of these medicines in tandem can raise glucose levels significantly enough to cause diabetes.
Why do diuretics increase blood glucose?
Basically, diuretics can affect glucose levels in the blood because they impair glucose metabolism. When the body cannot break down glucose as it should, the glucose level in the blood rises.
Why does thiazide diuretics cause hypercalcemia?
Hypercalcemia associated with thiazide use is a well-known clinical entity. Thiazides exert their antihypertensive effect through an increase in sodium excretion by blocking the thiazide-sensitive NaCl transporter in the distal convoluted tubule, which is closely linked to calcium transport (5).
What effect does thiazide diuretics have on glucose metabolism?
Several studies showed that use of thiazide diuretic increases glucose levels (4,12,26), but in these studies, the second drug was a β-blocker that impaired glucose metabolism.
How does potassium affect blood sugar levels?
If your potassium levels are too low, your body may make less insulin. That could lead to high blood sugar. Studies show that people with low potassium levels release less insulin, have higher blood sugar levels, and are more likely to get type 2 diabetes than those with normal potassium levels.
Does hydrochlorothiazide effect blood sugar?
Hydrochlorothiazide (HCTZ) and chlorthalidone are diuretics used to lower blood pressure but may increase your risk for high blood sugar and diabetes.
Does hydrochlorothiazide cause low blood sugar?
A 20% or greater rise in the fasting blood sugar occurred in 11 of 24 patients treated with 50 mg hydrochlorothiazide twice daily for six to ten weeks. The blood sugar decreased when potassium was given in conjunction with the diuretic, but the mean fasting blood sugar remained higher than pretreatment levels.
Why do thiazide diuretics cause hypokalemia?
Because loop and thiazide diuretics increase sodium delivery to the distal segment of the distal tubule, this increases potassium loss (potentially causing hypokalemia) because the increase in distal tubular sodium concentration stimulates the aldosterone-sensitive sodium pump to increase sodium reabsorption in …
What is the mechanism of action of thiazide diuretics?
Mechanism of action Thiazide diuretics control hypertension in part by inhibiting reabsorption of sodium (Na+) and chloride (Cl−) ions from the distal convoluted tubules in the kidneys by blocking the thiazide-sensitive Na+-Cl− symporter.
What medications can cause hyperglycemia?
Systemic Corticosteroid s (e.g. Prednisone) Decreases Glucose uptake
Does hydrochlorothiazide cause hyperglycemia?
Yes. Hydrochlorothiazide can cause hyperglycemia (increased blood glucose levels). Still looking for answers? Try searching for what you seek or ask your own question.
How do Thiazides cause hyperlipidemia?
Hyperlipidemia is prevalent in hypertension, but the cause of this association is unknown. Treatment of hypertension with thiazide diuretics accentuates the hyperlipidemia, perhaps by causing potassium or sodium depletion.
Why does hypokalemia with diuretics?
Diuretics are commonly used to treat high blood pressure (hypertension) because they lower blood pressure by helping your body eliminate sodium and water through your urine. However, some diuretics can also cause you to eliminate more potassium in your urine. This can lead to low potassium levels in your blood (hypokalemia).