Does omeprazole cause dementia?

Does omeprazole cause dementia?

Three studies have found a positive association between dementia and omeprazole, esomeprazole, lansoprazole, and pantropazole, with an approximately 1.4-fold increased risk of any dementia in cohorts using PPIs (95% CI, 1.36–1.52; P < 0.001) [76].

Can omeprazole affect memory?

The most common PPIs in use were omeprazole (Prilosec), pantoprazole (Protonix), and esomeprazole (Nexium). All participants were free of dementia at the study’s beginning. Yet, after the eight-year follow-up, chronic PPI users had a 44% increased risk of dementia compared with those who did not take any medication.

Can omeprazole cause confusion?

If you take omeprazole for more than 3 months, the levels of magnesium in your blood may fall. Low magnesium can make you feel tired, confused, dizzy and cause muscle twitches, shakiness and an irregular heartbeat. If you get any of these symptoms, tell your doctor.

Do proton pump inhibitors increase the risk of dementia?

Some experimental18 and clinical19 studies in recent years have found that proton pump inhibitors (PPIs) are associated with an increased risk of dementia and AD. PPIs block the H+ and K+-ATPase and, as a result, suppress the secretion of gastric acid.

Which antacid causes dementia?

Boustani said earlier studies have linked another type of antacid, H2 blockers, with an increased risk of dementia. Up to now, he’s recommended that patients use PPIs to treat acid reflux and steer clear of H2 blockers like Tagamet, Pepcid and Zantac.

What are the bad side effects of omeprazole?

Side Effects

• Back, leg, or stomach pain.
• bleeding or crusting sores on the lips.
• blisters.
• bloody or cloudy urine.
• continuing ulcers or sores in the mouth.
• difficult, burning, or painful urination.
• frequent urge to urinate.
• general feeling of discomfort or illness.

Do antacids cause dementia?

Study: Long term use of antacids could lead to increased risk for dementia. If you’re taking prescription heartburn pills, experts say you may want to be concerned. A recently published study shows that using antacids for a long duration may increase the risk of developing dementia.

Do acid reducers cause dementia?

They work by lowering the amount of acid produced by the stomach. But German researchers found that people 75 or older who regularly take the medications had a 44 percent increased risk of dementia, compared with seniors not using the drugs.

Why do PPIs cause dementia?

First, PPIs may affect amyloid-beta (Aβ) metabolism, one of the pathological markers of Alzheimer’s disease (AD). There is evidence that PPIs could cross the blood-brain barrier, enhance Aβ levels in the brain and decrease Aβ degradation.