What is the mechanism of action of atorvastatin?
Mechanism of Action Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. [2] By preventing the conversion of HMG-CoA to mevalonate, statin medications decrease cholesterol production in the liver.
What is indication of atorvastatin?
Hyperlipidemia. LIPITOR is indicated: As an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels and to increase HDL-C in adult patients with primary hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson Types IIa and IIb);
Is atorvastatin an enzyme inhibitor?
Atorvastatin is a statin medication and a competitive inhibitor of the enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol biosynthesis.
Why is atherosclerosis asymptomatic for decades?
Atherosclerosis is asymptomatic for decades because the arteries enlarge at all plaque locations, thus there is no effect on blood flow. Even most plaque ruptures do not produce symptoms until enough narrowing or closure of an artery, due to clots, occurs.
What are the complications of advanced atherosclerosis?
These complications of advanced atherosclerosis are chronic, slowly progressive and cumulative. Most commonly, soft plaque suddenly ruptures (see vulnerable plaque ), causing the formation of a thrombus that will rapidly slow or stop blood flow, leading to death of the tissues fed by the artery in approximately five minutes.
How do I schedule an appointment to discuss arteriosclerotic aortic disease?
To schedule an appointment to discuss arteriosclerotic aortic disease or any other cardiovascular condition, call us at 888-287-1082 or visit our Make a Cardiovascular Appointment page, where you may fill out a Patient Appointment Request Form and view other details about scheduling an appointment.
How fast does atherosclerosis progress as we age?
In some people, atherosclerosis progresses rapidly in their 30s. In others, it doesn’t become dangerous until they reach their 50s or 60s. (Some hardening of the arteries is normal as people age.) Exactly how atherosclerosis starts or what causes it isn’t known.
https://www.youtube.com/watch?v=OHE1ig4k64M