What is the content of artesunate?
Artesunate is a white or almost white powder with a molecular weight of 384.43. The chemical name is butanedioic acid, mono[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12Hpyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester. The empirical formula is C19H28O8.
What is malaria medicine made of?
Malaria has long been treated with plant-based medicine. Quinine, which comes from the bark of a cinchona tree, was first isolated as an antimalarial compound in the 1800s, though there is evidence that bark extracts have been used to treat malaria since the 1600s. The cinchona tree is native to Peru.
What is Artequick?
Artequick® is a fixed-dosed combination of artemisinin (80 mg), piperaquine (400 mg) and primaquine (4 mg) per tablet (Artepharm, China). Primaquine is included in the formulation with the intent of eliminating the gametocytes of P. falciparum.
What is antimalarial used for?
Antimalarial medication is used to prevent and treat malaria. You should always consider taking antimalarial medicine when travelling to areas where there’s a risk of malaria.
Why is artesunate diluted with sodium bicarbonate?
Artesunate is poorly soluble in water and has poor stability in aqueous solutions at neutral or acid pH. Artesunic acid is sufficiently soluble in sodium bicarbonate injection (50 mg/ml) to prepare a clear solution [2].
How do you mix IV artesunate?
Dilution for intravenous (IV) injection Using a syringe, add 5 ml of sodium chloride 0.9% for injection to the vial containing the reconstituted artesunate solution. This will yield 6 ml of a solution containing artesunate 10 mg/ml. 2. Shake to mix well, ensuring that the resulting solution is still clear.
Is Artemisinin the same as chloroquine?
Artemisinin combination therapy (ACT) is recommended as first-line treatment for uncomplicated Plasmodium falciparum malaria, whereas chloroquine is still commonly used for the treatment of non-falciparum species (Plasmodium vivax, Plasmodium ovale and Plasmodium malariae).
What is Artequin used for?
Mefloquine and Artequin are two effective antimalarial drugs currently in use in the treatment of uncomplicated malaria.
How do you take Ciprotab 500mg?
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ciprotab 500mg Tablet may be taken with or without food, but it is better to take it at a fixed time.
What are the ingredients in chloroquine?
Chloroquine phosphate tablets: The active substance is chloroquine phosphate. Each tablet contains 250 mg of chloroquine phosphate (equivalent to 155 mg chloroquine base). The other ingredients are magnesium stearate (E572) and maize starch.
How do you mix artesunate IM?
1. Mix the Artesunic acid powder with 1ml of 5% Sodium bicarbonate and shake for 2-3 minutes. The powder is difficult to dissolve and care should be taken to shake the mixture until the solution becomes clear.