What is osteosarcoma pathology?
Abstract. Osteosarcoma of bone is a tumor composed of malignant cells that produce osteoid. Some tumors show predominant chondroid or fibromatoid ground substance. All, however, are highly malignant and about 80 per cent produce death with metastases.
What is osteosarcoma histology?
In conventional intramedullary osteosarcoma , the predominant histologic pattern may be osteoblastic, fibroblastic, chondroblastic, giant cell rich, malignant fibrous histiocytoma like or partially telangiectatic.
Can osteosarcoma be cured?
Today, about 3 out of 4 people who have osteosarcoma can be cured if the cancer hasn’t spread to other parts of the body. Almost everyone who is treated with limb-sparing surgery ends up with that arm or leg working well. Many people who have osteosarcoma will need physical therapy for several months after surgery.
Can you survive osteosarcoma?
Survival rates can give you an idea of what percentage of people with the same type and stage of cancer are still alive a certain amount of time (usually 5 years) after they were diagnosed….Osteosarcoma 5-year relative survival rates.
| SEER stage | 5-year relative survival rate |
|---|---|
| Distant | 27% |
| All SEER stages combined | 60% |
What are the complications of osteosarcoma?
Complications of osteosarcoma and its treatment include: Cancer that spreads (metastasizes). Osteosarcoma can spread from where it started to other areas, making treatment and recovery more difficult. Osteosarcoma that spreads most often spreads to the lungs and to other bones.
What is the most common site for a conventional osteosarcoma?
Where does osteosarcoma start?
- Most tumors develop in the bones around the knee, either in the lower part of the thigh bone (distal femur) or the upper part of the shinbone (proximal tibia).
- The upper arm bone close to the shoulder (proximal humerus) is the next most common site.
Who is most affected by osteosarcoma?
Most osteosarcomas occur in children, teens, and young adults between the ages of 10 and 30. Teens are the most commonly affected age group, but people of any age can develop osteosarcoma. About 1 in 10 osteosarcomas occur in people older than 60.
What does high grade osteosarcoma mean?
High grade: Most osteosarcomas are high grade, meaning they will probably grow and spread quickly if not treated. The usual treatment for these cancers is as follows: Biopsy to establish the diagnosis. Chemotherapy (chemo), usually for about 10 weeks.
What is the histologic pattern of osteosarcoma?
In conventional intramedullary osteosarcoma , the predominant histologic pattern may be osteoblastic, fibroblastic, chondroblastic, giant cell rich, malignant fibrous histiocytoma like or partially telangiectatic. The age of presentation of osteosarcoma occurs chiefly in two groups : 10 25 years of age, and more than 60 years of age.
What genes are involved in osteosarcoma?
Genes involved and Proteins. Abnormalities of the RB gene are commonly seen in osteosarcoma but other components of the RB-pathway gene can be subject to genetics alterations : INK4, p16, CDK4 and cyclin D1. The INK4A gene located on chromosome 9p21 is inactivated in about 10 % of osteosarcomas.
What is periosteal osteosarcoma?
Periosteal osteosarcoma: an intermediate grade malignant bone and cartilage forming neoplasm arising on the cortical surface of a bone (the periosteum) Most cases are primary; secondary cases (usually after radiation therapy) represent a minority of cases
What is osteosarcoma of the femur?
Bone: Osteosarcoma. Conventional osteosarcoma shows a marked predilection for the metaphyseal regions of the long bones. The distal femur accounts for one third of all cases, followed by proximal tibia, and the proximal humerus. The most common presenting complaint is pain, usually from 1 to 8 months duration.