How can stent thrombosis be prevented?

How can stent thrombosis be prevented?

Potential stent modifications to reduce stent thrombosis have included improving the biocompatibility of the stent and polymer, using bioabsorbable polymers, eliminating the polymer entirely, and/or using stent surface modifications to stimulate vascular endothelialization.

Can stents cause thrombosis?

Stent thrombosis is a major complication associated with stent placement in percutaneous coronary intervention (PCI). Stent thrombosis has been associated with high rates of morbidity and mortality, often leading to events of cardiac death or nonfatal myocardial infarction (MI).

Why is paclitaxel used in stents?

Paclitaxel is released from the balloon or stent to prevent scar tissue formation in the blood vessel that can re-obstruct the artery (restenosis).

Does aspirin prevent stent thrombosis?

In conclusion, a 2-year dual antiplatelet regimen with aspirin and clopidogrel can prevent the occurrence of very late stent thrombosis after PCI with DESs.

How do you prevent blood clots after a stent?

You can decrease your risk for blood clots after stent placement by:

1. maintaining a healthy weight.
2. controlling your blood pressure.
3. watching your cholesterol.
4. exercising regularly.
5. refraining from smoking.

What is the mechanism of action of paclitaxel?

Mechanism of action of paclitaxel. Paclitaxel targets microtubules. At high concentration, PTX causes mitotic arrest at G2/M phase whereas at low concentration, apoptosis is induced at G0 and G1/S phase either via Raf-1 kinase activation or p53/p21 depending on the dose concentration.

What is the life of a medicated stent?

How long will a stent last? It is permanent. There is just a 2–3 per cent risk of narrowing coming back, and if that happens it is usually within 6–9 months. If it does, it can potentially be treated with another stent.

When can I stop Plavix after a stent?

The data “suggest that all patients with drug-eluting stents should continue to take [Plavix] for at least 12 months after [stent implantation], and possibly indefinitely,” Eisenstein and colleagues conclude.

What happens if a stent clots?

Stent thrombosis is a thrombotic occlusion of a coronary stent. This is usually an acute process in contrast to restenosis, which is a gradual narrowing of the stent lumen due to neointimal proliferation. Stent thrombosis often results in an acute coronary syndrome, while restenosis often results in anginal symptoms.