What is the difference between multiple myeloma and plasmacytoma?
Multiple myeloma is not confined to a specific bone or location within a bone. It tends to involve the entire skeleton. When only one lesion is found it is called a “plasmacytoma.” Most doctors believe that plasmacytoma is simply an early, isolated form of multiple myeloma.
What type of cancer is solitary plasmacytoma?
Solitary plasmacytoma (SP) is an early-stage plasma cell malignancy that is in between monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) along the spectrum of plasma cell disorders. A plasmacytoma is a discrete, solitary mass of neoplastic monoclonal plasma cells.
What is solitary plasmacytoma of bone?
Solitary plasmacytoma of bone (SPB, also called osseous plasmacytoma) is a localized tumor in the bone comprised of a single clone of plasma cells in the absence of other features of MM (ie, anemia, hypercalcemia, renal insufficiency, or multiple lytic bone lesions) [6,7].
What is multiple plasmacytoma?
Multiple solitary plasmacytoma (MSP) is a rare plasma cell dyscrasia, characterised by multiple lesions of neoplastic monoclonal plasma cells. It differs from multiple myeloma by the lack of hypercalcaemia, renal insufficiency, anaemia and pathological monoclonal plasmocytosis on a random bone biopsy.
Is Plasmacytoma malignant?
Plasmacytoma is a rare hematological malignancy characterized by a discrete, solitary mass of neoplastic monoclonal plasma cells that occurs either (1) inside (solitary bone plasmacytoma – SBP) or outside (extramedullary plasmacytoma – EMP) the bone.
What does plasmacytoma mean?
Plasmacytoma refers to a tumour consisting of abnormal plasma cells that grows within the soft tissue or bony skeleton.
What causes solitary plasmacytoma?
Causes of Solitary plasmacytoma. The specific cause is unknown but risk factors appear to be: Exposure to radiation. Family history of the condition. Exposure to carcinogens. more causes…».
What is the prognosis of solitary bone plasmacytoma (SBP)?
Approximately 30% of patients with solitary bone plasmacytoma (SBP) remain disease-free for several years; some of these patients may be cured. Patients with the best prognosis are those in whom the monoclonal protein disappears by 1 year after radiotherapy .
What is the prognosis of extramedullary plasmacytoma (EMP)?
Patients with EMP have a 5-year survival rate of about 82% and 10-year disease-specific survival rate greater than 50%. [ 11] The rate of progression to multiple myeloma is lower than in SBP, ranging from 11% to 30% at 10 years. [ 14]
Is plasmacytoma curable?
Furthermore, clonal rearrangements of immunoglobulin genes typical of B-cell neoplasms can be demonstrated in plasmacytomas by molecular genetic studies. Solitary plasmacytoma (plasma cell tumor) is the only known potentially curable plasma cell disorder. It can arise in bone or soft tissue.