What is KRAS wild-type?
Listen to pronunciation. (KAY-ras jeen) A gene that makes a protein that is involved in cell signaling pathways that control cell growth, cell maturation, and cell death. The natural, unchanged form of the gene is called wild-type KRAS.
What does wild-type mean in oncology?
A term used to describe a gene when it is found in its natural, non-mutated (unchanged) form. Mutated (changed) forms of certain genes have been found in some types of cancer. Knowing whether a patient’s tumor has a wild-type or mutated gene may help plan cancer treatment.
Is Erbitux the same as cetuximab?
Cetuximab is the generic name for the trade name drug Erbitux®. In some cases, health care professionals may use the trade name Erbitux® or other name C225 when referring to the generic drug name Cetuximab. Drug type: Cetuximab is an anti-cancer (“anti-neoplastic”) targeted therapy.
Who makes cetuximab?
(Eli Lilly and Company (NYSE: LLY) and Bristol-Myers Squibb Company (NYSE: BMY) today announced that the U.S. Food and Drug Administration (FDA) has approved ERBITUX® (cetuximab), in combination with platinum-based chemotherapy with 5-fluorouracil (CT), for the first-line treatment of recurrent locoregional or …
What is the difference between a wild type and a mutant type?
wild type An individual having the normal phenotype; that is, the phenotype generally found in a natural population of organisms. mutant An individual having a phenotype that differs from the normal phenotype.
What is wild type tp53?
Wild-type p53 is a sequence-specific transcription factor that when activated by various stresses, such as DNA damage, oncogenic signaling or nutrient depletion, promotes cellular outcomes, such as cell arrest, cell death, senescence, metabolic changes, and others, depending on the extent and context of the stress ( …
What is the difference between mutant and wild type?
How long can you have cetuximab?
The treatment break rule refers to NHS England’s policy imposed on advanced bowel cancer drugs cetuximab and panitumumab, where planned breaks from treatment longer than six weeks are not allowed.
Is cetuximab an immunotherapy?
Immunotherapy with monoclonal antibodies, such as avelumab and cetuximab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
How much does cetuximab cost?
The Costs of Cancer Treatments
| Drug (brand name) | Regimen | Total cost ‡ |
|---|---|---|
| Cetuximab (Erbitux) | Loading: 400 mg/m 2 ; maintain: 250 mg/m 2 /wk | $80 352 |
| Bevacizumab (Avastin) | 10 mg/kg every 14 d | $90 816 |
| Erlotinib (Tarceva) | 150 mg daily | $15752 |
| Sorafenib (Nexavar) | 400 mg twice a day | $34373 |
How effective is cetuximab?
Cetuximab also has activity as monotherapy in patients with recurrent and/or metastatic SCCHN who had failed platinum-based chemotherapy,. with a 12.6% response rate, disease control rate of 46%, and median response duration of ~ 6 months.
Is the wild type always dominant?
There are only ever two alleles for one character. The wild type allele is always dominant.
How effective is cetuximab for K-Ras tumors?
Treatment with cetuximab as compared with supportive care alone was associated with almost a doubling of the median overall and progression-free survival among patients with wild-type K-ras tumors. There was no significant survival benefit from cetuximab, however, among patients with tumors that had K-ras mutations.
How many patients with colorectal cancer are randomly assigned to cetuximab?
We analyzed tumor samples, obtained from 394 of 572 patients (68.9%) with colorectal cancer who were randomly assigned to receive cetuximab plus best supportive care or best supportive care alone, to look for activating mutations in exon 2 of the K-ras gene.
Who are the authors of cetuximab?
List of authors. Sonia Robitaille, M.Sc., Treatment with cetuximab, a monoclonal antibody directed against the epidermal growth factor receptor, improves overall and progression-free survival and preserves the quality of life in patients with colorectal cancer that has not responded to chemotherapy.
What is the dosage for cetuximab?
Cetuximab was given as an intravenous loading dose of 400 mg per square meter of body-surface area, administered over a period of 120 minutes, on day 1 of treatment, followed by an infusion of 250 mg per square meter, administered over a period of 60 minutes, once a week.