What is Zonisamide Zonegran used for?

What is Zonisamide Zonegran used for?

Zonisamide is used with other medications to prevent and control seizures (epilepsy). Zonisamide is a sulfonamide anticonvulsant and a carbonic anhydrase inhibitor. It is unknown how zonisamide works to prevent seizures.

What is the brand name for zonisamide?

The common brand name for Zonisamide is Zonegran (ZAHN-uh-gran).

Has zonisamide been discontinued?

The Food and Drug Administration (FDA or Agency) has determined that ZONEGRAN (zonisamide) capsules, 50 milligrams (mg), was not withdrawn from sale for reasons of safety or effectiveness.

What are the side effects of Zonegran?

COMMON side effects

• agitation.
• drowsiness.
• dizziness.
• decreased appetite.
• headache.
• nausea.

Is zonisamide used for anxiety?

Results from this pilot and open naturalistic study suggest that zonisamide may effectively augment response to anxiolytic medications in patients with treatment refractory anxiety. Larger and controlled studies are warranted to confirm these preliminary findings.

Is zonisamide a mood stabilizer?

Zonegran (zonisamide) is used with other medicines to help control partial seizures. It can’t be used by itself. Prevents seizures and stabilizes mood.

Is zonisamide the same as Keppra?

Zonegran (zonisamide) and Keppra (levetiracetam) are anticonvulsants used to treat seizures in patients with epilepsy. Side effects of Zonegran and Keppra that are similar include drowsiness, dizziness, tired feeling, and loss of appetite.

How does Zonegran make you feel?

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away.

Is zonisamide addictive?

Zonisamide is a new anti-epileptic drug whose mechanism of action is associated with neurotransmission systems also involved in the pathogenesis of addiction. Recently, the role of memory processes and the hippocampus (Hp) is underlined in dependence.

Can zonisamide cause weight gain?

Longitudinal assessment indicated that zonisamide was associated with a significantly slower rate of BMI and weight increases compared with placebo (P = . 01). No patients in the zonisamide group experienced significant weight gain, compared with 33% of placebo-treated patients (P = . 009).

What is the volume of distribution of zonisamide in humans?

The apparent volume of distribution (V/F) of zonisamide is about 1.45 L/kg following a 400 mg oral dose. Zonisamide, at concentrations of 1.0–7.0 µg/mL, is approximately 40% bound to human plasma proteins. Protein binding of zonisamide is unaffected in the presence of therapeutic concentrations of phenytoin, phenobarbital or carbamazepine.

Is zonisamide a carbonic anhydrase inhibitor?

Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures. Zonisamide may be a carbonic anhydrase inhibitor although this is not one of the primary mechanisms of action.

What is zonisamide used to treat?

Zonisamide is used in combination with other medications to treat certain types of seizures. Zonisamide is in a class of medications called anticonvulsants.

Does zonisamide cause elevated aminotransferase levels?

Zonisamide has not been associated with elevations in serum aminotransferase levels and clinically apparent drug induced liver disease has been reported with its use but is very rare. Zonisamide is a 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.