What is Deldel 6Q?

What is Deldel 6Q?

del(6q) is one of the most frequent cytogenetic aberration occurring in 10-20% of cases and often associated with 14q11 or del(9p) abnormalities. Prognosis. outcome similar to cases with normal diploid karyotypes.

What is deletion of 6q?

Deletion of 6q is an infrequent abnormality seen mostly in conjunction with a complex karyotype. However, as a sole abnormality it is very rare, described in isolated cases of MDS and AML (Hirata et al 1992; Gozzetti et al, 2009). The clinical significance of deletion 6q is not clear, due to small number of patients.

How many deletions of 6q are there in NHL?

The deletions of 6q are variable in size and have heterogeneous breakpoints. Based on chromosome analysis, Offit et al identified three regions of minimal cytogenetic deletions in a series of 94 NHL patients with deleted 6q; these regions were 6q21, 6q23, and 6q25-27 (Offit et al 1993).

What is a “large deletion” on chromosome 6?

Analysis showed a “large deletion” covering the entire arm of chromosome 6 (7 patients) and an “intermediate” deletion, a deletion always affecting the 6q telomeric region but not the 6q12 centromeric region (12 patients); deletions other than the two were classified as “interstitial” (51 patients).