Does IGF-1 increase blood sugar?

Does IGF-1 increase blood sugar?

The side effects of IGF-1 may be similar to those of other growth hormones. These include overgrowth of body tissues, known as acromegaly, and damage to the joints, liver, and heart. IGF-1 can cause your blood glucose levels to drop.

Does IGF-1 decrease glucose?

Administration of IGF-I to patients with extreme insulin resistance results in improvement in glycemic control and IGF-I has been shown to be associated with lowering glucose and enhancing insulin sensitivity in both type 1 and type 2 diabetes.

How does IGF-1 affect insulin?

IGF-1 and growth hormone (GH) interact with insulin to modulate its control of carbohydrate metabolism. A new study (see the related article beginning on page 96) shows that blocking the effect of GH in the presence of low serum IGF-1 concentrations enhances insulin sensitivity.

Why does IGF-1 cause hypoglycemia?

Due to its insulin-like action, the most common side-effect to exogenous IGF-1 is hypoglycemia, which occurs in a dose-dependent manner [27]. Insulin-like growth factor 1 (IGF-1) receptor α is overexpressed in pancreatic islets in nesidioblastosis and administration of recombinant IGF-1 causes hypoglycemia [27], [28].

Does insulin increase IGF-1?

Insulin may also increase the circulating IGF-I/IGFBP-3 ratio by increasing hepatic growth hormone sensitivity. The increased IGF-I bioavailability may, over time, increase the risk of colorectal cancer.

Does IGF-1 cause insulin resistance?

CONCLUSIONS. Low- and high-normal IGF-I levels are both related to insulin resistance. The biological mechanism of this complex phenomenon has to be elucidated in more detail for future risk stratification.

Does IGF-I affect insulin sensitivity and Type 2 diabetes?

IGF-I has an almost 50% amino acid sequence homology with insulin and elicits nearly the same hypoglycemic response ( 2 ). Several studies have investigated the effect of IGF-I on insulin sensitivity and its relation to type 2 diabetes.

Does IGF-I mimic insulin?

At high doses, IGF-I may mimic insulin, but at levels resulting in unacceptable “acromegalic” IGF-I levels and side-effects. The most exciting data concerning IGF-I is with a low dose where IGF-I improves insulin sensitivity by an unknown mechanism.

What is IGF-I (IGF-I)?

IGF-I, predominantly synthesized in the liver upon stimulation by growth hormone (GH), is usually bound to IGF-binding protein 3 (IGFBP-3) in circulation ( 1 ). IGF-I has an almost 50% amino acid sequence homology with insulin and elicits nearly the same hypoglycemic response ( 2 ).

How does IGF-I affect glucose homeostasis?

In general, the effects of IGF-I in the control of glucose homeostasis is well known. Animal models showed that a deletion of hepatic IGF-I production, resulting in 80% reduced IGF-I levels, led to hyperinsulinemia and abnormal glucose clearance ( 8, 9 ).