What does VMAT2 do?
The vesicular monoamine transporter 2 (VMAT2) is an integral presynaptic protein that regulates the packaging and subsequent release of dopamine and other monoamines from neuronal vesicles into the synapse.
What happens if you block VMAT?
More specifically, inhibition of VMAT2 may cause an increase in cytosolic catecholamine levels, which can result in an increase in efflux of catecholamines through the cell membrane, depleting catecholamine concentrations and causing increased oxidative stress and oxidative damage to the neuron.
What does the VMAT do?
Vesicular monoamine transporter (VMAT) is a vesicle membrane protein that functions as a transporter of amine neurotransmitters from the cytoplasm into synaptic vesicles and secretory granules of neurons, neuroendocrine cells, platelets, and mast cells (Erickson and Eiden, 1993; Erickson et al., 1996).
What type of transporter is DAT?
Abstract. The dopamine transporter (DAT) is a transmembrane protein that is responsible for the reuptake of dopamine (DA) from the synaptic cleft and for the termination of dopaminergic transmission.
What is the difference between VMAT and IMRT?
VMAT is a type of IMRT technique. VMAT stands for Volumetric Arc Therapy. VMAT can also be called Rapid Arc. VMAT is different to normal IMRT in that the radiotherapy machine rotates around the patient during a radiotherapy beam in an arc shape.
What is VMAT inhibitor?
VMAT inhibitors are drugs that act to inhibit the vesicular monoamine transporters.
Where is the VMAT2 gene located?
brain
In the brain, VMAT2 proteins are located on synaptic vesicles. VMAT2 transports monoamine neurotransmitters from the cytosol of monoamine neurons into vesicles.
How do VMAT2 inhibitors work?
Vesicular monoamine transporter 2 (VMAT2) inhibitors, which deplete dopamine at presynaptic striatal nerve terminals, are a class of drugs that have long been used to treat hyperkinetic movement disor … The basal ganglia and dopaminergic pathways play a central role in hyperkinetic movement disorders.
Who are the actors in Transporter The series?
Transporter: The Series: With Chris Vance, François Berléand, Charly Hübner, Violante Placido. Frank Martin is an ex special ops, who now spends his life as a transporter on the other side of the law.
Is there a transporter TV series in Canada?
Transporter: The Series (French: Le Transporteur : la série) is an English-language French-Canadian action-thriller television series, a spin-off from the Transporter film series created by Luc Besson and Robert Mark Kamen.
What is transtransporter season 2?
Transporter – The Series: Season 2 is an exciting, emotional, witting, adrenaline-fuelled twelve part series which will have the audience sitting on the edge of their seats as Frank drives them (sometimes quite literally!) through the twists and turns of each episode. — Atlantique Production One man, Three rules, One goal…