What is furin inhibitor?
Furin inhibitors are potential antiviral agents for SARS-CoV-2 infection and pathogenesis.
Is furin secreted?
Thus, our results suggest that membrane-bound furin undergoes post-translational processing to produce a soluble form of the enzyme that can be secreted.
Is furin intracellular?
Furin is a cellular endoprotease that was identified in 1990 (BOX 1); it proteolytically activates large numbers of proprotein substrates in secretory pathway compartments. These range from growth factors and receptors to extracellular-matrix proteins and even other protease systems that control disease.
What is TMPRSS2 inhibitor?
TMPRSS2 has an extracellular protease domain capable of cleaving a spike protein domain to initiate membrane fusion. Considering the vital role played by TMPRSS2 in the viral life cycle, this protease has received great attention to be used as a potential target to inhibit viral entry into host cells.
Is Furin a serine protease?
Among them, TMPRSS2 and furin play major roles in proteolytic activation of a broad range of viruses (reviewed in references 9, 10, and 11). TMPRSS2 is a type II transmembrane serine protease (TTSP) that is widely expressed in epithelial cells of the respiratory, gastrointestinal, and urogenital tract (11, 12).
Is furin a membrane protein?
Furin, a ubiquitous membrane protein, is initially produced as a ∼104-kDa precursor and is rapidly converted into an active ∼98-kDa form. This autocatalytic cleavage, occurring in the ER, is a prerequisite for the exit of mature furin molecules from the ER to the TGN and cell surface.
What does the word furin mean?
furinnoun. A protease found in certain animal cells.
Is Furin a membrane protein?
What class protease is Furin?
Furin protease belongs to the family of calcium (Ca2+)-dependent proprotein/prohormone convertases (PCs) that are ubiquitously expressed in humans, and its levels are significantly elevated in lung cystic fibrosis.
Is furin a serine protease?
What class protease is furin?
What is a furin-like pro-protein convertase?
A furin-like pro-protein convertase has been implicated in the processing of RGMc (also called hemojuvelin ), a gene involved in a severe iron-overload disorder called juvenile hemochromatosis.
Do furin-like proprotein convertases (PPCs) convert 50 kDa HJV to 40 kDa proteins?
Both the Ganz and Rotwein groups demonstrated that furin-like proprotein convertases (PPC) are responsible for conversion of 50 kDa HJV to a 40 kDa protein with a truncated COOH-terminus, at a conserved polybasic RNRR site.
What is the function of furfurin?
Furin cleaves these sections and activates the proteins. It was named furin because it was in the upstream region of an oncogene known as FES. The gene was known as FUR (FES Upstream Region) and therefore the protein was named furin. Furin is also known as PACE (Paired basic Amino acid Cleaving Enzyme).
What does furin stand for?
Furin is a protease enzyme that in humans is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these sections and activates the proteins. It was named furin because it was in the upstream region of an oncogene known as FES.