What does CCL2 stand for?
Introduction. Monocyte chemoattractant protein-1 [MCP-1, chemokine nomenclature: C–C motif chemokine ligand 2 (CCL2)] is a member of the chemokine family, a collection of small, secreted, chemotactic cytokines, named after their best known function of attracting cells (1).
What is CCL2 in immunology?
CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection.
What is CCL2 gene?
CCL2 (C-C Motif Chemokine Ligand 2) is a Protein Coding gene. Diseases associated with CCL2 include Neural Tube Defects and Human Immunodeficiency Virus Type 1. Among its related pathways are ERK Signaling and Folate Metabolism.
What is the role of CCL2?
CCL2/CCR2 signaling is best known for its role in regulating macrophage recruitment and polarization during inflammation. CCL2 regulates cellular adhesion and chemotaxis of macrophages through activation of β1 integrins and p38MAPK signaling pathways (Ashida, Arai, Yamasaki, & Kita, 2001).
What is MCP in blood?
However, whether blood PTX3 level can be used as an indicator of clinical RA disease activity is unknown. Another new mediator of inflammation, monocyte chemotactic protein-1 (MCP-1), is chemotactic for monocytes, basophils, T cells, and mast cells [19].
Does CCL5 exist?
Function. CCL5 is an 8kDa protein classified as a chemotactic cytokine or chemokine. CCL5 is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites.
What is the function of MCP?
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases.
What induces CCL2?
CCL2 is induced by RANKL in mononuclear precursor cells,311 and enhances the ability of RANKL to stimulate osteoclast-like cell formation in these cells. Treatment of monocytes with CCL2 alone induced the production of multinucleated- and calcitonin receptor-positive cells.
Where is CCR7 found?
CCR7 Chemokine Receptor CCR7 is expressed in various lymphoid tissues including B and T lymphocytes and mature dendritic cells (DC).
What is the receptor for CCL2?
CCL2 (monocyte chemoattractant protein-1, MCP-1) is a potent chemokine for monocytes, and a variety of other immune cells. Its receptor is CCR2, which is expressed at high levels on monocytes. CCL2 is produced by osteoblasts in response to PTH and proinflammatory cytokines.
Is MCP-1 pro or anti inflammatory?
In summary, our data suggest that MCP-1 may be a necessary component of the inflammatory response required for adipose tissue protection, remodeling, and healthy expansion in the FVB/N strain in response to HFD feedings.
What does high CCL5 mean?
Abstract. We found that high levels of serum C‐C motif chemokine ligand 5 (CCL5), a chemokine produced by immune cells, were significantly associated with improved prognosis of patients with operated breast cancer.
Anti-CCL2 Antibody Products. CCL2 is a symbol for the gene, Chemokine (C-C motif) ligand 2, in humans.
What is the function of cdccl2?
CCL2 regulates the migration and infiltration of monocytes, memory T lymphocytes, and NK cells and is implicated in the pathogeneses of several diseases characterized by monocytic infiltrates, such as multiple sclerosis, psoriasis, rheumatoid arthritis, and atherosclerosis.
What is the best way to neutralize the biological effects of CCL2?
The 2H5 antibody has been shown to neutralize the biological effects of CCL2 in vivo. The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. Brunner, P. M., et al. (2015).
How many kilodaltons in mass is CCL2?
Structurally, the protein is reported to be 11 kilodaltons in mass. Based on gene name, canine, porcine, monkey, mouse and rat orthologs may also be found. Antibodies to the CCL2 antigen may be useful for studying cytokine signaling.