What is metformin ER 1000 mg used for?
Metformin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. It is used in patients with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems.
What is the best time of day to take metformin ER?
Standard metformin is taken two or three times per day. Be sure to take it with meals to reduce the stomach and bowel side effects that can occur – most people take metformin with breakfast and dinner. Extended-release metformin is taken once a day and should be taken at night, with dinner.
What is the difference between metformin and metformin ER?
Metformin and metformin ER are not the same. Metformin is the immediate-release version while metformin ER is the extended-release version. Metformin is approved to treat type 2 diabetes in adults and children aged 10 years and older while metformin ER is only approved to treat type 2 diabetes in adults.
What are the benefits of metformin ER?
Extended-release metformin improves GI tolerability, allows once-daily dosing, and is currently available in multiple branded and generic formulations; however, it is more expensive than immediate-release metformin.
Does metformin ER help you lose weight?
All things considered, metformin can cause a modest reduction in weight, most likely due to side effects, like a decreased appetite and an upset stomach. But although effective for weight loss, the drug doesn’t replace traditional dieting methods.
Is it safe to take metformin ER?
The American Diabetes Association (ADA) recommends both metformin and metformin ER because they are both inexpensive and safe and because they’ve been shown to reduce the risk of diabetes complications for people who use them long term.
Can metformin ER be taken twice a day?
Many studies have demonstrated that once or twice daily administration of ER metformin is as safe and efficacious as twice daily IR metformin, overall providing continued glycemic control for up to 24 weeks of treatment [5].
How long does it take for metformin ER to take effect?
How long does it take to work? Metformin does not instantly reduce blood sugar levels. The effects are usually noticeable within 48 hours of taking the medication, and the most significant effects take 4–5 days to occur.
What are the side effects of metformin ER?
Nausea, vomiting, stomach upset, diarrhea, gas, weakness, or a metallic taste in the mouth may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. If stomach symptoms return later (after taking the same dose for several days or weeks), tell your doctor right away.
How long does it take for metformin ER to work?
Metformin does not instantly reduce blood sugar levels. The effects are usually noticeable within 48 hours of taking the medication, and the most significant effects take 4–5 days to occur.
Can I take metformin ER twice a day?
Can in vivo bioequivalence testing be waived for metformin approval?
Data are examined regarding possible waiver of in vivo bioequivalence testing (i.e. biowaiver) for approval of metformin hydrochloride (metformin) immediate-release solid oral dosage forms. Data include metformin’s Biopharmaceutics Classification System (BCS) properties, including potential excipient interactions.
Is the bioavailability of the test product inferior to innovator metformin?
The bioavailability of the test product was not inferior to innovator metformin. Metformin is an oral antidiabetic drug (OAD) belonging to the biguanide class.
Is there a bioequivalence of generic metformin tablets in Nigeria?
The availability of generic products permits generic substitution with a much-reduced cost of treatment. However, only generic products that offer similar bioavailability with the innovator should be considered. This study was designed to assess the bioequivalence of generic metformin tablets within Nigeria.
Are metmetformin tablets approved for quality in the United States?
Metformin tablets selected from the Nigerian market were appraised for quality following British and United States Pharmacopoeia guidelines. In vivo bioequivalence study in healthy volunteers was applied for a generic and the innovator brand in an open-label, 2-arm, 2-treatment crossover fashion with a 1-week washout period.