Does hypophosphatemia cause osteomalacia?

Does hypophosphatemia cause osteomalacia?

Low blood phosphate (hypophosphatemia) leads to rickets or osteomalacia. In early childhood, bowing deformities of the legs reflect softened bones. Growth is impaired, frequently resulting in short stature. In adults, there is osteomalacia.

Can osteomalacia be Tumour induced?

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism caused by typically small endocrine tumors that secrete fibroblast growth factor 23 (FGF23).

What is oncogenic osteomalacia?

Oncogenic osteomalacia — also referred to as tumor-induced osteomalacia (TIO) — is a rare endocrine disorder in which a small bony or soft tissue mesenchymal tumor causes hypophosphatemia via secretion of FGF23 .

What is tumor-induced rickets?

Tumor-induced osteomalacia/rickets (TIO) is a rare paraneoplastic disorder caused by overproduction of fibroblast growth factor 23 (FGF23) from the responsible tumors. 1,2. FGF23 is a hormone associated with decreased resorption of phosphate that causes hyperphosphaturia, leading to osteomalacia or rickets.

What causes Hypophosphatemia?

Hypophosphatemia is most often caused by long-term, relatively low phosphate intake in the setting of a sudden increase in intracellular phosphate requirements such as occurs with refeeding. Intestinal malabsorption can contribute to inadequate phosphate intake, especially if coupled with a poor diet.

What are the symptoms of hypophosphatemia?

Some of the tell-tale signs you might have hypophosphatemia, include:

• Muscle weakness.
• Softening or weakening of bones.
• Chronic depletion.
• Depletion of muscles.
• Issues with the blood.
• Altered mental state.
• Seizures.
• Numbness.

What are mesenchymal tumors?

Mesenchymal tumors include entities originating from mesodermal-derived precursor cells that develop into bone, cartilage, or other connective tissues, such as blood vessels, adipose tissue, smooth muscle, or fibroblasts; in the CNS they most commonly arise from the meninges rather than the CNS parenchyma.

What is Phosphaturic mesenchymal tumors?

Phosphaturic mesenchymal tumor (PMT) is a rare mesenchymal neoplasm associated with tumor-induced osteomalacia (TIO), a paraneoplastic syndrome that manifests as renal phosphate wasting caused by elevated serum FGF23. Besides osteomalacia, the clinical presentation includes bone pain and multiple bone fractures.

What is Xlink hypophosphatemia?

X-linked hypophosphatemia (XLH) is an inherited disorder characterized by low levels of phosphate in the blood. Phosphate levels are low because phosphate is abnormally processed in the kidneys, which causes a loss of phosphate in the urine (phosphate wasting) and leads to soft, weak bones (rickets).