For which type of cancer is sorafenib indicated?

For which type of cancer is sorafenib indicated?

NEXAVAR® is indicated for the treatment of patients with unresectable hepatocellular carcinoma (HCC). NEXAVAR is indicated for the treatment of patients with advanced renal cell carcinoma (RCC).

Can sorafenib cure HCC?

Sorafenib is a new multikinase inhibitor, which has been shown to exhibit a significant anticancer effect in the treatment of solid tumors. It has been approved for the treatment of advanced RCC, and was recently found to improve survival of patients with advanced HCC as compared to placebo when used as monotherapy.

Can you stop taking sorafenib?

Be sure to tell your doctor how you are feeling during your treatment with sorafenib. Continue to take sorafenib even if you feel well. Do not stop taking sorafenib without talking to your doctor.

How do you dissolve sorafenib?

Dissolve 100 mg of Sorafenib in 2.5mL of a stock solution containing 75% Ethanol and Cremophor EL（1:1）at 60°C (40mg/mL). 3. Vortex at highest speed and put back on 60°C, until Sorafenib is completely dissolved (This process can take up to 15 min).

How effective is sorafenib for hepatocellular carcinoma (HCC)?

In late-stage hepatocellular carcinoma (HCC), sorafenib is currently an effective first-line therapy. Unfortunately, the development of drug resistance to sorafenib is becoming increasingly common.

Is sorafenib effective for advanced renal cell carcinoma?

Sorafenib®is a multikinase inhibitor that has recently obtained Food and Drug Administration (FDA) approval for the treatment of advanced renal cell carcinoma (RCC). It has been tried in several solid tumors, including HCC. A recent phase III trial has shown that sorafenib significantly extends survival for patients with advanced HCC.

How does sorafenib work in the body?

Abstract. Sorafenib exerts its action through inhibition of several kinases involved in both tumour cell proliferation and angiogenesis. It was well tolerated at a dose of 400 mg twice daily and permanent discontinuation of the drug was rarely required.

Is sorafenib a tumor suppressor or oncogenes?

After sorafenib treatment, oncogenes tend to be hypermethylated, while tumor suppressor genes tend to be hypomethylated. In addition, the lncRNA H19 is an example of maternal expression and epigenetic regulation of imprinted gene products and is believed to promote or inhibit tumors.