How does adipose tissue cause inflammation?
Adipose tissue is now considered to be an active endocrine organ that secretes various humoral factors (adipokines), and its shift to production of proinflammatory cytokines in obesity likely contributes to the low-level systemic inflammation that is seen in metabolic syndrome-associated chronic pathologies such as …
What happens when adipocytes undergo hypertrophy?
Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Moreover, high-fat feeding increases the rate of adipose cell size growth, independent of strain, reflecting the increase in calories requiring storage.
Does adipose tissue trigger inflammation?
The triggers for adipose tissue inflammation are still poorly defined. However, obesity-induced adipose tissue expansion provides a plethora of intrinsic signals (e.g., adipocyte death, hypoxia, and mechanical stress) capable of initiating the inflammatory response.
What happens if adipose tissue is damaged?
More commonly, too much adipose tissue leads to obesity, mainly from too much visceral fat. Obesity leads to a number of serious health problems. Obesity increases the risk of developing type 2 diabetes as it causes the body to become resistant to insulin.
What causes adipocyte hyperplasia?
Hyperplasia is enhanced by high-fat diet in a strain-dependent way, suggesting a synergistic interaction between genetics and diet. Moreover, high-fat feeding increases the rate of adipose cell size growth, independent of strain, reflecting the increase in calories requiring storage.
What is the function of adipocyte?
The Adipocyte as Functional Endocrine Cell The classical function of the adipocyte is as a calorie storage system accepting chemical energy in the form of glucose and fatty acid from the blood and converting these metabolites to TG for storage during fed conditions via lipogenesis.