How is CUROSURF administered?

How is CUROSURF administered?

Administer CUROSURF suspension through the proximal end of the secondary lumen of the endotracheal tube as a single dose, given over 1 minute, and without interrupting mechanical ventilation.

How fast does CUROSURF work?

CUROSURF improves oxygenation within 5 minutes and rapidly reduces FiO2 requirements over the initial treatment period—delivering better short-term efficacy. Physiological end points (eg, faster reduction in FiO2) have not been proven to impact key clinical outcomes such as mortality due to RDS.

How many doses of surfactant?

Dosages have varied from 25 mg to 200 mg phospholipids/kg body weight as single doses in the different clinical trials. Studies of different dosing regimens are limited. Surfactant-TA (a natural bovine surfactant) was more effective at a dose of 120 mg/kg than 60 mg/kg (54).

How do you give Beractant?

Administration

1. Slowly withdraw the entire contents of the vial into a plastic syringe through a large-gauge needle (e.g., at least 20 gauge).
2. Attach the premeasured 5 French end-hole catheter to the syringe.
3. When administering SURVANTA using a 5 French end-hole catheter, administer in four quarter-dose aliquots.

Is curosurf synthetic?

Animal-derived surfactants that contain surfactant proteins (Survanta, Infasurf, and Curosurf) perform clinically better than Exosurf, a synthetic surfactant containing only phospholipids, primarily in outcomes related to acute management of respiratory distress syndrome (RDS; faster weaning and pneumothorax) but not …

How late can surfactant be given?

Ideally the dose should be given within 1 hr of birth but definitely before 2 hours of age. A repeat dose should be given within 4 – 12 hours if the patient is still intubated and requiring more than 30 to 40% oxygen.

What is Curosurf made from?

CUROSURF is a natural surfactant, prepared from porcine lungs, containing almost exclusively polar lipids, in particular phosphatidylcholine (about 70% of the total phospholipid content), and about 1% of specific low molecular weight hydrophobic proteins SP-B and SP-C.

What is intratracheal route?

Intratracheal instillation is the introduction of a substance directly into the trachea. It is widely used to test the respiratory toxicity of a substance as an alternative to inhalation in animal testing.

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