Is CD47 an immune checkpoint?

Is CD47 an immune checkpoint?

CD47 is a novel macrophage immune checkpoint that plays a broad role in cancer immune evasion across multiple cancer types and particularly in myeloid malignancies.

Do macrophages express CD47?

CD47 : SIRPα as a macrophage checkpoint in cancer ‘Marker of self’ membrane protein CD47 is normally expressed on all cells and binds with weak, sub-micromolar affinity to ‘signal regulatory protein’ SIRPα on macrophages, including precursor monocytes.

Is CD47 an innate immune checkpoint for tumor evasion?

Thus, CD47 is a checkpoint molecule for both innate and adaptive immunity for tumor evasion.

What is Magrolimab?

A humanized monoclonal antibody targeting the human cell surface antigen CD47, with potential immunostimulating and antineoplastic activities.

Is CD47 a receptor?

Cluster of Differentiation 47 (CD47) is an integral membrane receptor containing a heavily glycosylated N-terminal IgV-like extracellular domain (ECD), a 5-transmembrane (5-TM) spanning helical bundle domain, and a small, C-terminal domain (CTD).

Where is CD47 found?

CD47 is a kind of protein that is found on the surface of many cells in the body. It tells circulating immune cells called macrophages not to eat these cells. The body uses the CD47 protein to protect cells that should be protected and to help dispose of cells that are aged or diseased.

Is Magrolimab FDA approved?

Magrolimab has been granted Fast Track Designation by the FDA for the treatment of MDS, acute myeloid leukemia (AML), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. Magrolimab has also been granted Orphan Drug Designation by the FDA for MDS and AML and by the European Medicines Agency for AML.

What is the function of CD47?

CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent “don’t eat me” signal to prevent phagocytosis.

What contains CD47?

CD47 is ubiquitously expressed in human cells, including red blood cells (RBCs) and platelets, and the expression of its different isoforms is tissue specific4.

What type of drug is azacitidine?

Azacitidine is in a class of medications called demethylation agents. It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells in the bone marrow.