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What are the characteristics of a good drug target?
Key aspects to be considered are a high unmet medical need (no drug is available or existing therapies have serious limitations with regard to efficacy or safety or both) and there is a reasonable market size. The full therapeutic potential of many drug targets is often not obvious at the time of their discovery.
Why is a drug target crucial in the success of drug discovery?
This is crucial because it means potentially there are many more drugs out there that are working through off-target binding; it also means that many other drug candidates that have previously been disregarded may have unrecognized promise.
How can a drug be targeted to a specific organ?
Active targeting is a non-invasive approach, in which the drug is transported to the target organ or tissue using site-specific ligands. The pairing of drug carriers, such as liposome, particulate nanocarrier etc., with a ligand leads to the specific targeting to selected cells.
How is drug target determined?
Target Identification & Characterization Target identification and characterization begins with identifying the function of a possible therapeutic target (gene/protein) and its role in the disease. Identification of the target is followed by characterization of the molecular mechanisms addressed by the target.
What are targets therapeutic?
Therapeutic target may refer to: Biological target, a protein or nucleic acid whose activity can be modified by an external stimulus. Therapeutic Targets Database, a database to provide information about the known and explored therapeutic targets. Therapeutic target range, an alternative reference range.
Why proteins are drug targets?
In order for a protein to have any potential as a drug target it must be druggable. A druggable protein is one that possesses folds that favour interactions with small drug-like molecules, be they endogenous or extraneous, and therefore is one that contains a binding site [1,3].
What are the reasons for drug targeting?
Targeted drug delivery to solid tumors is a very active research area, focusing mainly on improved drug formulation and associated best delivery methods/devices. Drug-targeting has the potential to greatly improve drug-delivery efficacy, reduce side effects, and lower the treatment costs.
What is the significance of drug targeting?
The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug side-effects, and reduced fluctuation in circulating drug levels.