Is idiopathic thrombocytopenic purpura genetic?
Currently, ITP is not usually considered an inherited disease. If multiple family members have been diagnosed with ITP, the hematologist should verify that the cause of low platelets is truly autoimmune and is not due to an inherited disorder that affects platelet production.
Is thrombocytopenia genetic or environmental?
Known as inherited thrombocytopenia or familial thrombocytopenia, low platelets are caused by a genetic mutation (or an inherited mutation), not by autoantibodies, as is the case with primary ITP. There are many forms of inherited thrombocytopenia, all of them rare.
What is the most common cause of immune thrombocytopenia purpura ITP in children?
Key points about ITP in children The cause is usually unknown, but it may be an autoimmune disorder or follow a viral illness. It can also occur with certain medications or vaccinations. Treatment may not be needed. The most common treatments are immune globulin or corticosteroids.
Does thrombocytopenia run in families?
Immune thrombocytopenia and other autoimmune disorders can run in families, but the inheritance pattern is usually unknown. People with a first-degree relative (such as a parent or sibling) with immune thrombocytopenia likely have an increased risk of developing the disorder themselves.
Who is at risk for thrombocytopenia syndrome?
Risk factors ITP is more common among young women. The risk appears to be higher in people who also have diseases such as rheumatoid arthritis, lupus and antiphospholipid syndrome.
What are some inherited platelet disorders?
Platelet Coagulant Function
| Disorder | Features |
|---|---|
| Bernard-Soulier syndrome | Autosomal recessive Absent GpIb/IX complex Severe platelet adhesion defect |
| Grey Platelet syndrome | Autosomal recessive inheritance Absence of platelet a granules Mild platelet dysfunction |