Is MCV normal in thalassemia?

Is MCV normal in thalassemia?

The RDW is normal in patients with thalassemia and anemia of chronic disease but high in those with iron deficiency. The MCV is decreased in iron-deficiency anemia and in thalassemia minor and normal or decreased in chronic disease.

Does low MCV mean thalassemia?

Patients who have thalassemia have an anemia associated with microcytosis (low MCV) and hypochromia (low MCH), although the extent of anemia can be highly variable.

How is alpha thalassemia silent carrier diagnosed?

Blood tests are usually normal. Your red blood cells may be smaller than normal. Being a silent carrier means you don’t have signs of the disease, but you can pass the damaged gene on to your child. This is confirmed by DNA tests.

What is silent alpha thalassemia carrier?

One missing or abnormal gene makes a child a silent alpha thalassemia carrier. Silent alpha thalassemia carriers have no signs or symptoms of the disease, but are able to pass thalassemia on to their children. Two missing or mutated genes is a condition called alpha thalassemia minor or having alpha thalassemia trait.

What should your MCV level be?

An MCV test measures the size and volume of red blood cells. A normal MCV range is roughly 80–100 fl . If someone’s MCV level is below 80 fl, they will likely develop or have microcytic anemia.

What is Thalassemia carrier?

A carrier of thalassaemia is someone who carries at least 1 of the faulty genes that causes thalassaemia, but does not have thalassaemia themselves. It’s also known as having the thalassaemia trait. If you’re a thalassaemia carrier, you will not develop thalassaemia.

Can thalassemia cause low white blood cell count?

Hypersplenism can contribute to anemia in individuals with beta thalassemia and cause low levels of white blood cells, increasing the risk of infection, and low levels of platelets, which can lead to prolonged bleeding.

Is ferritin high in thalassemia minor?

In patients with minor thalassemia and non-transfusion-dependent hemoglobinopathy, the prevalence of iron deficiency is lower due to serum ferritin levels compared to the normal population. High and very high ferritin is more common in intermediate thalassemia and hemoglobin H and sickle cells.

Can thalassemia go undetected?

Many individuals with beta thalassemia minor go through life never knowing they carry an altered gene for the disorder. A beta thalassemia major diagnosis is usually made during the first two years of life and individuals require regular blood transfusions and lifelong medical care to survive.

Can you donate blood if you have thalassemia trait?

You must not donate blood if you have had babesiosis. You will be permanently deferred. If you have G6PD (Glucose-6-Phosphate Dehydrogenase Deficiency) or Thalassemia (minor), you can donate blood if you meet the haemoglobin requirement.

What happens if both parents are silent carriers of alpha thalassemia?

If both parents carry alpha thalassemia trait in which the two abnormal genes of each parent are on opposite chromosomes, their children will inherit alpha thalassemia trait.

Can you donate blood if you have alpha thalassemia?

It is a common practice worldwide to accept blood from thalassemic carrier donors who meet the minimum Hb level for blood donation [6]. However, the exception is not applied to Hb S carrier; neither apheresis nor whole blood donations are allowed.

What does it mean to be a silent carrier of thalassemia?

One gene is missing or damaged, and the other 3 are normal. Blood tests are usually normal. Your red blood cells may be smaller than normal. Being a silent carrier means you don’t have signs of the disease, but you can pass the damaged gene on to your child. This is confirmed by DNA tests. Alpha thalassemia carrier.

What are the different types of alpha thalassemia?

There are 4 types of alpha thalassemia: Alpha thalassemia silent carrier. One gene is missing or damaged, and the other 3 are normal. Blood tests are usually normal. Your red blood cells may be smaller than normal. Being a silent carrier means you don’t have signs of the disease, but you can pass the damaged gene on to your child.

What is thalassemia (Thal-UH-See-Mee-UH)?

Thalassemia (thal-uh-SEE-mee-uh) is a blood disorder that is inherited. This means it is passed down from one or both parents through their genes. When you have thalassemia, your body makes less hemoglobin than normal. Hemoglobin is an iron-rich protein in red blood cells. It carries oxygen to all parts of the body.

What happens when you have thalassemia?

When you have thalassemia, your body makes less hemoglobin than normal. Hemoglobin is an iron-rich protein in red blood cells. It carries oxygen to all parts of the body. There are 2 main types of thalassemia: alpha and beta.