Is Temocillin narrow-spectrum?
It is plausible that, as a narrow-spectrum antibiotic, temocillin may be ecologically benign: certainly, old studies suggest little or no propensity to select for resistant pathogens or for overgrowth by Clostridium difficile.
What is temocillin used for?
Introduction: Temocillin is an alternative to treat urinary tract infections with bacteria producing extended spectrum beta-lactamase (ESBL).
Can you give Temocillin and amoxicillin?
This preliminary study suggests that the combination amoxicillin+temocillin is a viable alternative to piperacillin/tazobactam for the treatment of severe hospital-acquired pneumonia. This combination appears to be associated with fewer gastrointestinal adverse events.
Does temocillin cover Pseudomonas?
Temocillin is not active against Pseudomonas aeruginosa or Acinetobacter spp.
Is temocillin a penicillin?
Temocillin is a recently developed penicillin with a methoxy group in the 6-alpha position. The in vitro activity of temocillin was studied using 932 recent clinical isolates of aerobic and anaerobic Gram-negative bacilli and Gram-positive cocci, and its activity was compared with that of other beta-lactam antibiotics.
How do you give temocillin?
Temocillin for intravenous injection is diluted in 10 to 20 ml of sterile water; it is diluted in less than 2 ml of sterile water when being prepared for intramuscular injection; the continuous infusion is diluted in 48 ml of sterile water for ease of administration (2 ml per hour).
Is Temocillin a penicillin?
How do you give Temocillin?
Is temocillin an antibiotic?
Temocillin is a β-lactamase-resistant penicillin introduced by Beecham, marketed by Eumedica Pharmaceuticals as Negaban. It is used primarily for the treatment of multiple drug-resistant, Gram-negative bacteria….Temocillin.
| Clinical data | |
|---|---|
| show IUPAC name | |
| CAS Number | 66148-78-5 |
| PubChem CID | 171758 |
| ChemSpider | 150149 |
Is Temocillin an antibiotic?
How do you give IV Temocillin?
Manufacturer advises for intermittent intravenous infusion, give in Glucose 5% or 10% or Sodium chloride 0.9% or Ringer’s solution or Lactated Ringer’s solution. Reconstitute 1 g with 10 mL water for injections or infusion fluid, then dilute in up to 150 mL infusion fluid; give over 30–40 minutes.