What are Civatte bodies?
Civatte bodies (CBs) are seen as rounded, homogenous, eosinophilic masses on routine H and E staining lying in the deeper parts of epidermis/epithelium and more frequently in dermis/connective tissue. They are known as CBs (in epithelium/epidermis), colloid bodies, or hyaline bodies (in connective tissue).
What is Hypertrophic Lichen Planus?
Hypertrophic lichen planus (HLP) is the second most common cutaneous variant of lichen planus. It is characterized as extremely pruritic, and thick hyperkeratotic plaques are seen primarily on the shins or dorsal aspect of the foot and may be covered by a fine adherent scale.
Where are Civatte bodies found?
Degenerative keratinocytes, known as colloid or Civatte bodies, are found in the lower epidermis. In addition to apoptotic keratinocytes, colloid bodies are composed of globular deposits of IgM (occasionally immunoglobulin G [IgG] or immunoglobulin A [IgA]) and complement.
What are CMV inclusion bodies?
cytomegalovirus infection. Cytomegalic inclusion body disease (CIBD) also known as cytomegalic inclusion disease (CID) is a series of signs and symptoms caused by cytomegalovirus infection, toxoplasmosis or other rare infections such as herpes or rubella viruses.
What does lichen planus of the skin look like?
Lichen planus of the skin appears as small, flat-topped, red-to-purple bumps with round or irregular shape. You may have just a few small bumps or you may have many. If you take a closer look, you might see white scales or flakes on them. Some may have wispy, gray-to-white streaks called Wickham’s Striae.
What are Civatte bodies and where are they found?
K17+ speckles were identified as Civatte bodies, and they were mainly distributed in the interface between epithelial cells and lymphocytic infiltrates (type A, 52.8%), followed by distribution within the epithelial layer (type B, 24.7%) or within the lamina propria with lymphocytic infiltration (type C, 22.5%).
What do Civatte bodies in skin biopsies indicate?
The presence of numerous civatte bodies (CBs) in biopsies is a characteristic finding in skin lesions of patients with various dermatoses, particularly lichen planus (LP) and discoid lupus erythematosus (DLE). In the absence of a clear diagnosis, their presence is suggestive of disorders characterized by interface dermatitis.
What is poikiloderma of Civatte?
Poikiloderma of Civatte is a benign, common and chronic condition, which belongs to the group of melanodermas ( pigmented skin disorders). The term ‘poikiloderma’ refers to a skin change with atrophy where hypopigmentation / hyperpigmentation changes and dilation of the fine blood vessels (telangiectasia) can be seen in the affected skin.