What are demyelinating lesions?
A demyelinating disease is any condition that results in damage to the protective covering (myelin sheath) that surrounds nerve fibers in your brain, optic nerves and spinal cord. When the myelin sheath is damaged, nerve impulses slow or even stop, causing neurological problems.
What causes demyelinating lesions in the brain?
Triggers. Demyelination is often caused by inflammation that attacks and destroys myelin. Inflammation can occur in response to an infection, or it can attack the body as part of an autoimmune process. Toxins or infections can also harm myelin or may interfere with its production.
How serious is demyelinating disease?
This rare condition most often affects boys between ages 7 and 12. It wears away myelin in the brain and spinal cord. Severe cases can affect breathing, heart rate, and blood pressure.
Does demyelination always mean MS?
What is demyelination, and what causes it? Demyelination occurs when myelin, which is the protective coating of nerve cells, sustains damage. When this happens, neurological problems can occur. Demyelination can result from various medical conditions, including multiple sclerosis (MS).
Can demyelination cause headaches?
Headache associated with demyelinating lesions is characterized by clinical features that, in most cases, meet the ICHD-II criteria [1] for tension headache or migraine.
What are the signs of end stage multiple sclerosis?
These common symptoms may develop or worsen during the final stages of MS:
- Vision problems, including blurriness or blindness.
- Muscle weakness.
- Difficulty with coordination and balance.
- Problems with walking and standing.
- Feelings of numbness, prickling, or pain.
- Partial or complete paralysis.
- Difficulty speaking.
Can demyelination be reversed?
There’s no cure for demyelinating conditions, but new myelin growth can occur in areas of damage. However, it’s often thinner and not as effective.
Can demyelination be normal?
Not everyone is affected by demyelinating conditions in the same way. However, some demyelinating symptoms are very common. Early symptoms — which are among the first signs of demyelination — include: loss of vision.
Can a virus cause demyelination?
A number of viruses can initiate central nervous system (CNS) diseases that include demyelination as a major feature of neuropathology.
What are the clinical manifestations of a supratentorial lesion?
The clinical manifestations of a supratentorial lesion may be site specific and may produce localizing clinical manifestation. The lesion affecting the motor frontal cortex may be associated with contralateral hemiparesis. The tumors of speech area will result in aphasia.
What is the prognosis of a supratentorial mass lesion of the brain?
A supratentorial mass lesion may result in cognitive decline. The speed of growth of the lesions determine the nature of onset and progress of the signs and symptoms. Slow-growing tumors have an insidious onset of presentation and are gradually progressive. Rapidly expanding masses have fast progression.
How serious is supratentorial white matter disease?
Supratentorial white matter disease is a serious concern. The cerebrum is the largest part of the brain. Most occur in the white matter. White matter disease is a chronic condition. When lesions appear, the pathways are interrupted, and this results in an inability to pass directions to the body’s central nervous system from the gray matter.
What are the Hallmark lesions of demyelinating disease (MS)?
The hallmark lesions of demyelinating disease are within the white matter of the brain. The classical sequences that visualize MS plaques in vivoare T2 weighted imaging (T2WI) acquisition techniques, where lesions are sensitively detected with a hyperintense signal change (Figures 1Cand and2A).2A).