What are MOLM-13 cells?
MOLM-13 and MOLM-14 are the first cell lines with, and represent the third reported case of, MLL gene rearrangement arising via chromosomal insertion.
What is Nalm6?
Nalm6 is a B cell precursor leukemia cell line initiated from an adolescent male. It is a CD24-positive xenograft model of acute lymphoblastic leukemia.
What are Daudi cells?
The Daudi cell line is composed of B lymphoblasts isolated from the peripheral blood of a 16-year-old, Black, male, Burkitt’s Lymphoma patient in 1967. These well-characterized B lymphoblasts have been extensively used in the study of leukemogenesis. The line is a suitable transfection host, as well.
What is lymphoblastoid?
(LIM-foh-BLAST) A lymphocyte that has gotten larger after being stimulated by an antigen. Lymphoblast also refers to an immature cell that can develop into a mature lymphocyte. Enlarge. Blood cell development.
What is the relationship between molm-13 and molm-14?
MOLM-13 and MOLM-14 are the first cell lines with, and represent the third reported case of, MLL gene rearrangement arising via chromosomal insertion. Both cell lines carry trisomy 8 which was also present during the MDS phase, as well as the most frequent trisomies associated with t(9;11), ie, +6, +13, +19 variously present in different subclones.
How does densitometry differ between molm-13 and MV4–11?
In MOLM-13, densitometry confirmed a 75% reduction in Rb levels by 4 h ( p < 0.0001) and greater than 99% at 24 h, with a corresponding reduction in the phosphorylated form (p-Rb). In MV4–11, only a modest reduction in the levels of Rb and p-Rb at 4 h, with Rb level returning to baseline and a modest increase in p-Rb observed at 24 h (Fig. 2A, B ).
What is the role of FLT3 mutations in AML?
Recently, it has also been shown that FLT3 mutations may provide a growth stimulus for AML cells. Small internal tandem duplications (ITD) in the juxtamembrane part of the FLT3 gene in patients with AML have been reported by Nakao et al. FLT3 ITD were found in about 20% of AML cases.