What are the limitations of one compartment model?
DISADVANTAGES • Drug given by IV route may behave according to single compartment model but the same drug given by oral route may show 2 compartment behaviour. The type of compartment behaviour i.E. Type of compartment model may change with the route of administration. 22.
What are the assumptions of one compartment open model?
The one-compartment open model assumes that the body can be described as a single, uniform compartment (ie, one compartment), and that drugs can enter and leave the body (ie, open model). The simplest drug administration is when the entire drug is given in a rapid IV injection, also known as an IV bolus.
What does the Open mean in one compartment open model?
The one-compartment open model is the simplest way to describe the process of drug distribution and elimination in the body. This model assumes that the drug can enter or leave the body (ie, the model is “open”), and the entire body acts like a single, uniform compartment.
Which one is the reference compartment in one compartment open model?
The anatomical reference compartment is the plasma and concentration of drug in plasma is representative of drug concentration in all body tissues i.e. any change in plasma drug concentration reflects a proportional change in drug concentration throughout the body.
What does the word open mean in the one compartment open model Mcq?
Explanation: The term open indicates that the input and the output are unidirectional and the drug can be eliminated from the body. One compartment open model does not assume that drug concentration in plasma is equal to that in other body tissue.
Which compartment model is rarely used?
A single compartment model is the least accurate, as it assumes a homogeneous distribution of the drug in the body. A three-compartment model is the most useful for anaesthetic substances as it discriminates between fast-redistributing tissues (muscle) and slow tissues (fat)
Who poorly developed BBB?
Infants
3. Who has poorly developed BBB? Explanation: Infants are newly born. Their BBB is poorly developed.
What is surfactant Mcq?
It’s a substance which tends to decrement the surface tension of a liquid in which it’s dissolved in it. 2.