What are the signs and symptoms of nephrotoxicity?
If severe enough, nephrotoxicity can show signs of other types of decreased kidney function, such as decreased urination, swelling from fluid retention and high blood pressure. In some patients, nephrotoxicity can also affect other body systems such as the liver or the skin and show signs in those areas as well.
Which drug side effect is nephrotoxicity?
20 Drugs associated with this mechanism of nephrotoxicity include calcineurin inhibitors (e.g., cyclosporine, tacrolimus), certain chemotherapy agents, Chinese herbals containing aristocholic acid, and lithium.
How is nephrotoxicity detected?
Nephrotoxicity can be diagnosed through a simple blood test. Evaluation of nephrotoxicity through blood tests includes the measurements of blood urea nitrogen (BUN), concentration of serum creatinine, glomerular filtration rate and creatinine clearance.
What chemotherapy is nephrotoxic?
The most nephrotoxic chemotherapeutic drug is cisplatin, which is often associated with acute kidney injury. Many other drugs such as alkylating agents, antimetabolites, vascular endothelial growth factor pathway inhibitors and epidermal growth factor receptor pathway inhibitors may have toxic effects on the kidneys.
What are the symptoms when creatinine is high?
The disturbing symptoms of high creatinine in blood include: Swelling or edema. Shortness of breath. Nausea and vomiting. Changes in urination.
How do you treat nephrotoxicity?
Nephrotoxicity from IL-2 is generally reversible and managed by administering fluid boluses at the onset of oliguria [95,96]. Additionally, vasopressors such as low and intermediate-dose dopamine are used in treatment of oliguria and hypotension by cross-talk with adrenergic receptors [97,98].
How is nephrotoxicity treated?
Can chemo reverse kidney damage?
Some cancer treatments cause damage to the kidneys that can result in acute kidney failure. Kidney damage is usually reversible, if it is carefully managed to control the life-threatening complications.